Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1,The Journal of Clinical Investigation

当前位置： X-MOL 学术 › J. Clin. Invest. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1
The Journal of Clinical Investigation ( IF 13.3 ) Pub Date : 2021 , DOI: 10.1172/jci150452
Shivani Bhatt ₁ , Ansel T Hillmer _{2,

3,

4} , Aleksandra Rusowicz ₃ , Nabeel Nabulsi _{2,

4} , David Matuskey _{2,

3,

4} , Gustavo A Angarita _{3,

4} , Soheila Najafzadeh ₄ , Michael Kapinos ₄ , Steven M Southwick _{3,

5} , John H Krystal _{3,

5} , Richard E Carson _{3,

4} , Yiyun Huang _{2,

4} , Kelly P Cosgrove _{1,

2,

3,

4,

5}

Affiliation

BACKGROUND. Investigations of stress dysregulation in posttraumatic stress disorder (PTSD) have focused on peripheral cortisol, but none have examined cortisol in the human brain. This study used positron emission tomography (PET) to image 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a cortisol-producing enzyme, as a putative brain cortisol marker in PTSD.

中文翻译：

以 11β-羟基类固醇脱氢酶 1 型为靶点对 PTSD 中的脑皮质醇调节进行成像

背景。对创伤后应激障碍 (PTSD) 压力失调的研究主要集中在外周皮质醇，但没有人检测过人脑中的皮质醇。这项研究使用正电子发射断层扫描 (PET) 对 11β-羟基类固醇脱氢酶 1 型 (11β-HSD1) 进行成像，这是一种产生皮质醇的酶，可作为 PTSD 中推定的脑皮质醇标志物。

更新日期：2021-10-17

点击分享查看原文

点击收藏

阅读更多本刊最新论文