Altered metabolic patterns in tumor cells not only meet their own growth requirements but also shape an immunosuppressive microenvironment through multiple mechanisms. Noncoding RNAs constitute approximately 60% of the transcriptional output of human cells and have been shown to regulate numerous cellular processes under developmental and pathological conditions. Given their extensive action mechanisms based on motif recognition patterns, noncoding RNAs may serve as hinges bridging metabolic activity and immune responses. Indeed, recent studies have shown that microRNAs, long noncoding RNAs and circRNAs are widely involved in tumor metabolic rewiring, immune cell infiltration and function. Hence, we summarized existing knowledge of the role of noncoding RNAs in the remodeling of tumor metabolism and the immune microenvironment, and notably, we established the TIMELnc manual, which is a free and public manual for researchers to identify pivotal lncRNAs that are simultaneously correlated with tumor metabolism and immune cell infiltration based on a bioinformatic approach.

中文翻译：

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非编码 RNA 将代谢重编程与癌症中的免疫微环境联系起来


肿瘤细胞代谢模式的改变不仅满足其自身的生长需求，还通过多种机制塑造免疫抑制微环境。非编码RNA约占人类细胞转录输出的60%，并已被证明可以在发育和病理条件下调节许多细胞过程。鉴于其基于基序识别模式的广泛作用机制，非编码 RNA 可以作为桥接代谢活动和免疫反应的铰链。事实上，最近的研究表明，microRNA、长链非编码RNA和circRNA广泛参与肿瘤代谢重连、免疫细胞浸润和功能。因此，我们总结了非编码RNA在肿瘤代谢和免疫微环境重塑中的作用的现有知识，值得注意的是，我们建立了TIMELnc手册，这是一本免费的公共手册，供研究人员识别与非编码RNA同时相关的关键lncRNA。基于生物信息学方法的肿瘤代谢和免疫细胞浸润。