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Neurochemical Changes in the Brain After Fetal Exposure to Fluoxetine, A Serotonin Reuptake Inhibitor (SRI) in Rodents
Current Proteomics ( IF 0.5 ) Pub Date : 2021-07-31 , DOI: 10.2174/1570164617999201116154235
Mona Awad Alonazi 1 , Amina El Gezeery 1 , Afaf el-Ansary 2 , Ramesa Shafi Bhat 1
Affiliation  

Background: In utero exposure to Selective Serotonin Reuptake Inhibitors (SSRI) is considered a risk factor for many neurodevelopmental diseases.

Objective: The aim of this study was to investigate whether prenatal SSRI exposure changes newborn brain chemistry.

Methods: An animal-based study was designed in which the utero SSRI exposed rat pups were compared to one without drug exposure. Neurochemical changes in the infants were assessed after 2 days of birth by estimating the levels of inflammatory cytokines, neurotransmitters, and caspases in the brain exposed to SSRI at the prenatal stage and compared to normal unexposed newborns.

Results: Our results showed significant neurochemical changes in SSRI-exposed newborns. A significant decrease in dopamine, and serotonin levels with a remarkable decrease in noradrenaline in addition to remarkable increase of IFN-γ and caspase-3 levels was observed in the brain tissues of prenatal exposed SSRIs rat pups.

Conclusion: The results suggest that prenatal SSRI treatment may affect brain development of newborn hence should be done warily during the gestation period.



中文翻译:

胎儿接触氟西汀后大脑的神经化学变化,氟西汀是啮齿动物的一种血清素再摄取抑制剂 (SRI)

背景:在子宫内暴露于选择性血清素再摄取抑制剂 (SSRI) 被认为是许多神经发育疾病的危险因素。

目的:本研究的目的是调查产前 SSRI 暴露是否会改变新生儿脑化学。

方法:设计了一项基于动物的研究,其中将子宫 SSRI 暴露的大鼠幼崽与未暴露于药物的幼崽进行比较。通过估计出生前暴露于 SSRI 的大脑中炎性细胞因子、神经递质和半胱天冬酶的水平,并与正常未暴露的新生儿进行比较,评估婴儿出生 2 天后的神经化学变化。

结果:我们的结果显示暴露于 SSRI 的新生儿出现显着的神经化学变化。在产前暴露的 SSRIs 大鼠幼崽的脑组织中观察到多巴胺和血清素水平显着下降,去甲肾上腺素显着下降,此外 IFN-γ 和 caspase-3 水平显着增加。

结论:结果表明,产前SSRI治疗可能会影响新生儿的大脑发育,因此在妊娠期应谨慎行事。

更新日期:2021-07-31
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