The purpose of this study is to assess the effect of calcium bolus in response to a hypotensive episode by assessing high-fidelity hemodynamic data obtained from children with single-ventricle physiology with parallel circulation. Single-center, retrospective analysis of hemodynamic data after calcium bolus administrations within the first 2 weeks post-surgery. Time intervals were the baseline (− 60 to − 10 min); the hypotensive episode (− 10 to 0 min); time point zero at the bolus administration; and the response (0 to 60 min). The main responses assessed were the peak increase in mean blood pressure (mBP), duration of the response after the bolus, and markers of oximetric effects. These analyses included 128 boluses in 63 patients. Of the total boluses analyzed, 80% increased the mBP by 5 mmHg or higher with the effect lasting at least 10 min, whereas 10% of the boluses analyzed increased the mBP by 20 mmHg or higher with the effect lasting at least 50 min. The boluses induced a significant increase in arterial oxygen saturation and an upward trend in pulmonary-to-systemic flow ratio, without increasing renal or cerebral oxygen extraction ratios. Calcium chloride boluses are an effective rescue medication for hypotensive episodes in children with parallel circulation. They lead to an improvement in mBP, as well as an increase in pulmonary-to-systemic blood flow ratio. More importantly, these boluses do not compromise systemic oxygen delivery.

本研究的目的是通过评估从具有平行循环的单心室生理学儿童获得的高保真血流动力学数据来评估钙丸对低血压发作的反应。对术后前 2 周内给予钙丸后的血流动力学数据进行单中心回顾性分析。时间间隔是基线（- 60 到 - 10 分钟）；低血压发作（- 10 至 0 分钟）；推注给药的时间点为零；和响应（0 到 60 分钟）。评估的主要反应是平均血压 (mBP) 的峰值增加、推注后反应的持续时间和血氧影响的标志物。这些分析包括 63 名患者的 128 次推注。在分析的总推注中，80% 的 mBP 增加了 5 mmHg 或更高，效果持续至少 10 分钟，而分析的 10% 的推注使 mBP 增加 20 mmHg 或更高，效果持续至少 50 分钟。推注导致动脉血氧饱和度显着增加和肺-体流量比呈上升趋势，而没有增加肾或脑氧提取率。氯化钙丸剂是平行循环儿童低血压发作的有效急救药物。它们导致 mBP 的改善，以及肺与全身血流比率的增加。更重要的是，这些推注不会影响全身氧气输送。不增加肾或脑氧提取率。氯化钙丸剂是平行循环儿童低血压发作的有效急救药物。它们导致 mBP 的改善，以及肺与全身血流比率的增加。更重要的是，这些推注不会影响全身氧气输送。不增加肾或脑氧提取率。氯化钙丸剂是平行循环儿童低血压发作的有效急救药物。它们导致 mBP 的改善，以及肺与全身血流比率的增加。更重要的是，这些推注不会影响全身氧气输送。