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Potential of Producing Flavonoids Using Cyanobacteria As a Sustainable Chassis
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2021-10-14 , DOI: 10.1021/acs.jafc.1c04632 Haojie Jin 1 , Yan Wang 2 , Pengquan Zhao 1 , Litao Wang 1 , Su Zhang 1 , Dong Meng 1 , Qing Yang 1 , Ling-Zhi Cheong 3 , Yonghong Bi 4 , Yujie Fu 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2021-10-14 , DOI: 10.1021/acs.jafc.1c04632 Haojie Jin 1 , Yan Wang 2 , Pengquan Zhao 1 , Litao Wang 1 , Su Zhang 1 , Dong Meng 1 , Qing Yang 1 , Ling-Zhi Cheong 3 , Yonghong Bi 4 , Yujie Fu 1
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Numerous plant secondary metabolites have remarkable impacts on both food supplements and pharmaceuticals for human health improvement. However, higher plants can only generate small amounts of these chemicals with specific temporal and spatial arrangements, which are unable to satisfy the expanding market demands. Cyanobacteria can directly utilize CO2, light energy, and inorganic nutrients to synthesize versatile plant-specific photosynthetic intermediates and organic compounds in large-scale photobioreactors with outstanding economic merit. Thus, they have been rapidly developed as a “green” chassis for the synthesis of bioproducts. Flavonoids, chemical compounds based on aromatic amino acids, are considered to be indispensable components in a variety of nutraceutical, pharmaceutical, and cosmetic applications. In contrast to heterotrophic metabolic engineering pioneers, such as yeast and Escherichia coli, information about the biosynthesis flavonoids and their derivatives is less comprehensive than that of their photosynthetic counterparts. Here, we review both benefits and challenges to promote cyanobacterial cell factories for flavonoid biosynthesis. With increasing concerns about global environmental issues and food security, we are confident that energy self-supporting cyanobacteria will attract increasing attention for the generation of different kinds of bioproducts. We hope that the work presented here will serve as an index and encourage more scientists to join in the relevant research area.
中文翻译：
使用蓝藻作为可持续底盘生产类黄酮的潜力
许多植物次生代谢物对食品补充剂和药物都具有显着影响，以改善人类健康。然而，高等植物只能产生少量具有特定时空排列的这些化学物质，无法满足不断扩大的市场需求。蓝藻可以直接利用CO 2、光能和无机营养物，以在具有突出经济价值的大规模光生物反应器中合成多功能的植物特异性光合中间体和有机化合物。因此，它们已迅速发展为用于合成生物产品的“绿色”底盘。黄酮类化合物是基于芳香族氨基酸的化合物，被认为是各种营养品、药物和化妆品应用中不可或缺的成分。与酵母和大肠杆菌等异养代谢工程先驱相反，关于生物合成黄酮类化合物及其衍生物的信息不如其光合对应物的信息全面。在这里，我们回顾了促进蓝藻细胞工厂进行黄酮类生物合成的好处和挑战。随着对全球环境问题和粮食安全的日益关注，我们有信心能源自养蓝藻在生产不同种类的生物产品方面将受到越来越多的关注。我们希望这里介绍的工作可以作为索引，鼓励更多的科学家加入相关的研究领域。
更新日期：2021-10-27
中文翻译：
使用蓝藻作为可持续底盘生产类黄酮的潜力
许多植物次生代谢物对食品补充剂和药物都具有显着影响，以改善人类健康。然而，高等植物只能产生少量具有特定时空排列的这些化学物质，无法满足不断扩大的市场需求。蓝藻可以直接利用CO 2、光能和无机营养物，以在具有突出经济价值的大规模光生物反应器中合成多功能的植物特异性光合中间体和有机化合物。因此，它们已迅速发展为用于合成生物产品的“绿色”底盘。黄酮类化合物是基于芳香族氨基酸的化合物，被认为是各种营养品、药物和化妆品应用中不可或缺的成分。与酵母和大肠杆菌等异养代谢工程先驱相反，关于生物合成黄酮类化合物及其衍生物的信息不如其光合对应物的信息全面。在这里，我们回顾了促进蓝藻细胞工厂进行黄酮类生物合成的好处和挑战。随着对全球环境问题和粮食安全的日益关注，我们有信心能源自养蓝藻在生产不同种类的生物产品方面将受到越来越多的关注。我们希望这里介绍的工作可以作为索引，鼓励更多的科学家加入相关的研究领域。
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