In this contribution, data will be presented that suggest that certain cancer markers or their surrogates can be detected by infrared spectral imaging methodology. In particular, the co-localization of certain regions in spectral images with PD-L1-postive immunohistochemical response suggests that either the PD-L1 protein or a surrogate associated with its presence are detectable. In the case of Her2/neu, an analysis of mean spectral signatures of over forty thousand individual spectra revealed small, but statistically significant spectral differences between cancer marker positive and negative tissues in spectral regions associated with protein phosphorylation.

在这篇文章中，将提供数据表明某些癌症标志物或其替代物可以通过红外光谱成像方法检测到。特别是，光谱图像中某些区域与 PD-L1 阳性免疫组织化学反应的共定位表明，可以检测到 PD-L1 蛋白或与其存在相关的替代物。在 Her2/neu 的情况下，对超过四万个单独光谱的平均光谱特征的分析揭示了与蛋白质磷酸化相关的光谱区域中癌症标志物阳性和阴性组织之间的微小但统计学上显着的光谱差异。