PBK Model-Based Prediction of Intestinal Microbial and Host Metabolism of Zearalenone and Consequences for its Estrogenicity,Molecular Nutrition & Food Research

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PBK Model-Based Prediction of Intestinal Microbial and Host Metabolism of Zearalenone and Consequences for its Estrogenicity
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2021-10-14 , DOI: 10.1002/mnfr.202100443
Diana M Mendez-Catala ₁ , Qianrui Wang ₁ , Ivonne M C M Rietjens ₁

Affiliation

The aim of the present study is to develop physiologically-based kinetic (PBK) models for rat and human that include intestinal microbial and hepatic metabolism of zearalenone (ZEN) in order to predict systemic concentrations of ZEN and to obtain insight in the contribution of metabolism by the intestinal microbiota to the overall metabolism of ZEN.

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