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PBK Model-Based Prediction of Intestinal Microbial and Host Metabolism of Zearalenone and Consequences for its Estrogenicity
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2021-10-14 , DOI: 10.1002/mnfr.202100443
Diana M Mendez-Catala 1 , Qianrui Wang 1 , Ivonne M C M Rietjens 1
Affiliation  

The aim of the present study is to develop physiologically-based kinetic (PBK) models for rat and human that include intestinal microbial and hepatic metabolism of zearalenone (ZEN) in order to predict systemic concentrations of ZEN and to obtain insight in the contribution of metabolism by the intestinal microbiota to the overall metabolism of ZEN.

中文翻译:


基于 PBK 模型的肠道微生物和玉米赤霉烯酮宿主代谢及其雌激素性后果的预测



本研究的目的是为大鼠和人类开发基于生理学的动力学 (PBK) 模型,其中包括玉米赤霉烯酮 (ZEN) 的肠道微生物和肝脏代谢,以预测 ZEN 的全身浓度并深入了解代谢的贡献由肠道微生物群影响 ZEN 的整体代谢。
更新日期:2021-12-03
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