Critical Assessment of the Reducing Ability of Breslow-type Derivatives and Implications for Carbene-Catalyzed Radical Reactions**,Angewandte Chemie International Edition

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Critical Assessment of the Reducing Ability of Breslow-type Derivatives and Implications for Carbene-Catalyzed Radical Reactions**
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2021-10-15 , DOI: 10.1002/anie.202111988
Ludivine Delfau ₁ , Samantha Nichilo ₁ , Florian Molton ₁ , Julie Broggi ₂ , Eder Tomás-Mendivil ₁ , David Martin ₁

Affiliation

A major cleanup for starting anew: Bio-inspired Breslow-type enolates, which mimic thiamine derivatives, are far better reducing agents than previously considered. The reevaluation of the redox ability of these key intermediates refutes established misconceptions and sheds a new light on radical processes involving N-heterocyclic carbene catalysis.