The effect of limb remote ischaemic conditioning (RIC) on myocardial infarct (MI) size and left ventricular ejection fraction (LVEF) was investigated in a pre-planned cardiovascular magnetic resonance (CMR) substudy of the CONDI-2/ERIC-PPCI trial. This single-blind multi-centre trial (7 sites in UK and Denmark) included 169 ST-segment elevation myocardial infarction (STEMI) patients who were already randomised to either control (n = 89) or limb RIC (n = 80) (4 × 5 min cycles of arm cuff inflations/deflations) prior to primary percutaneous coronary intervention. CMR was performed acutely and at 6 months. The primary endpoint was MI size on the 6 month CMR scan, expressed as median and interquartile range. In 110 patients with 6-month CMR data, limb RIC did not reduce MI size [RIC: 13.0 (5.1–17.1)% of LV mass; control: 11.1 (7.0–17.8)% of LV mass, P = 0.39], or LVEF, when compared to control. In 162 patients with acute CMR data, limb RIC had no effect on acute MI size, microvascular obstruction and LVEF when compared to control. In a subgroup of anterior STEMI patients, RIC was associated with lower incidence of microvascular obstruction and higher LVEF on the acute scan when compared with control, but this was not associated with an improvement in LVEF at 6 months. In summary, in this pre-planned CMR substudy of the CONDI-2/ERIC-PPCI trial, there was no evidence that limb RIC reduced MI size or improved LVEF at 6 months by CMR, findings which are consistent with the neutral effects of limb RIC on clinical outcomes reported in the main CONDI-2/ERIC-PPCI trial.

CONDI-2/ERIC-PPCI 试验的一项预先计划的心血管磁共振 (CMR) 子研究研究了肢体远程缺血调节 (RIC) 对心肌梗死 (MI) 大小和左心室射血分数 (LVEF) 的影响。这项单盲多中心试验（英国和丹麦的 7 个地点）纳入了 169 名 ST 段抬高型心肌梗死 (STEMI) 患者，这些患者已被随机分为对照组 ( n = 89) 或肢体 RIC ( n = 80) (4 × 在初次经皮冠状动脉介入治疗之前进行 5 分钟的手臂袖带充气/放气循环。 CMR 在 6 个月时紧急进行。主要终点是 6 个月 CMR 扫描的 MI 大小，以中位数和四分位数范围表示。在 110 名具有 6 个月 CMR 数据的患者中，肢体 RIC 并未减少 MI 大小 [RIC：左室质量的 13.0 (5.1–17.1)%；对照：与对照相比，LV 质量的 11.1 (7.0–17.8)%， P = 0.39] 或 LVEF。在 162 名有急性 CMR 数据的患者中，与对照组相比，肢体 RIC 对急性 MI 大小、微血管阻塞和 LVEF 没有影响。在前壁 STEMI 患者亚组中，与对照组相比，RIC 与急性扫描时微血管阻塞发生率较低和 LVEF 较高相关，但这与 6 个月时 LVEF 的改善无关。总之，在 CONDI-2/ERIC-PPCI 试验的这项预先计划的 CMR 子研究中，CMR 没有证据表明肢体 RIC 减少了 MI 大小或改善了 6 个月时的 LVEF，这些结果与肢体 RIC 的中性效应一致。主要 CONDI-2/ERIC-PPCI 试验中报告的 RIC 临床结果。