Salmonella enterica   serovar Infantis is the fifth most common   Salmonella   serovar isolated in England and Wales. Epidemiological, genotyping and antimicrobial-resistance data for   S  .   enterica   Infantis isolates were used to analyse English and Welsh demographics over a 5 year period. Travel cases associated with   S  .   enterica   Infantis were mainly from Asia, followed by cases from Europe and North America. Since 2000, increasing numbers of   S  .   enterica   Infantis had multidrug resistance determinants harboured on a large plasmid termed ‘plasmid of emerging   S  .   enterica   Infantis’ (pESI). Between 2013 and 2018, 42   S  .   enterica   Infantis isolates were isolated from humans and food that harboured resistance determinants to multiple antimicrobial classes present on a pESI-like plasmid, including extended-spectrum β-lactamases (ESBLs; bla CTX-M-65). Nanopore sequencing of an ESBL-producing human   S  .   enterica   Infantis isolate indicated the presence of two regions on an IncFIB pESI-like plasmid harbouring multiple resistance genes. Phylogenetic analysis of the English and Welsh   S  .   enterica   Infantis population indicated that the majority of multidrug-resistant isolates harbouring the pESI-like plasmid belonged to a single clade maintained within the population. The bla CTX-M-65 ESBL isolates first isolated in 2013 comprise a lineage within this clade, which was mainly associated with South America. Our data, therefore, show the emergence of a stable resistant clone that has been in circulation for some time in the human population in England and Wales, highlighting the necessity of monitoring resistance in this serovar.

中文翻译：

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英格兰和威尔士的 pESI 样质粒的表征和多重耐药婴儿肠沙门氏菌分离物的分析


婴儿肠沙门氏菌血清型是英格兰和威尔士分离出的第五种最常见沙门氏菌血清型。 S的流行病学、基因分型和抗菌药物耐药性数据。 Enterica Infantis 分离株用于分析 5 年期间的英国和威尔士人口统计数据。与S相关的旅行箱。婴儿肠杆菌主要来自亚洲，其次是欧洲和北美病例。自 2000 年以来， S的数量不断增加。 Enterica Infantis 具有多药耐药性决定簇，该决定簇隐藏在称为“新兴沙门氏菌质粒”的大质粒上。婴儿肠杆菌(pESI)。 2013 年至 2018 年间，42 S .婴儿肠杆菌分离株是从人类和食物中分离出来的，这些菌株对 pESI 样质粒上存在的多种抗菌药物类别具有耐药性决定因素，包括超广谱 β-内酰胺酶（ESBL； bla CTX-M-65 ）。对产生 ESBL 的人类S进行纳米孔测序。 Enterica Infantis 分离株表明 IncFIB pESI 样质粒上存在两个含有多个抗性基因的区域。英格兰和威尔士S的系统发育分析。 Enterica Infantis 种群表明，大多数携带 pESI 样质粒的多重耐药分离株属于种群内维持的单一进化枝。 bla CTX-M-65 ESBL 分离株于 2013 年首次分离，包含该分支内的一个谱系，主要与南美洲有关。因此，我们的数据显示出现了一种稳定的耐药克隆，该克隆已经在英格兰和威尔士的人群中流通了一段时间，这凸显了监测该血清型耐药性的必要性。