Reduced Intensity Conditioning (RIC) transplantation is increasingly offered to older patients with acute myeloblastic leukemia (AML). We have previously shown that a RIC allograft, particularly from a sibling donor is beneficial in intermediate risk patients aged 35-65 years. We here present analyses from the NCRI AML16 trial extending this experience to older patients aged 60-70 inclusive lacking favorable risk cytogenetics 932 patients were studied, with RIC transplant in first remission given to 144 (sibling n=52, MUD n=92) with median follow-up for survival from CR of 60 months. Comparisons of transplant versus not are carried out using Mantel-Byar analysis. Among the 144 allografts, 93 had intermediate risk cytogenetics, 18 adverse and 33 were unknown. In transplanted patients survival was 37% at 5 years, and while the survival for siblings (44%) was better than that for MUDs (34%) this was not significant (p=0.2). When comparing RIC versus chemotherapy survival was significantly improved (37% vs 20%, HR 0.67 (0.53-0.84) p.

中文翻译：

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60 至 70 岁的老年患者因急性髓细胞白血病接受减低强度移植的结果：NCRI 急性髓细胞白血病 16 试验的结果。

降低强度调节 (RIC) 移植越来越多地提供给患有急性髓细胞白血病 (AML) 的老年患者。我们之前已经表明，RIC 同种异体移植物，特别是来自同胞供体的移植物对 35-65 岁的中危患者有益。我们在此展示了来自 NCRI AML16 试验的分析，该试验将这种经验扩展到 60-70 岁的老年患者（包括缺乏有利的细胞遗传学风险） 研究了 932 名患者，RIC 移植在第一次缓解时给予 144 名（兄弟姐妹 n=52，MUD n=92）从 CR 开始的中位随访生存期为 60 个月。使用 Mantel-Byar 分析进行移植与不移植的比较。在 144 例同种异体移植物中，93 例细胞遗传学为中危，18 例不良，33 例未知。移植患者的 5 年生存率为 37%，虽然兄弟姐妹的存活率 (44%) 好于 MUD (34%)，但这并不显着 (p=0.2)。当比较 RIC 与化疗时，存活率显着提高（37% 与 20%，HR 0.67 (0.53-0.84) p.