Translating basic pain research from rodents to humans has proven to be a challenging task. Efforts have been made to develop preclinical large animal models of pain, such as the pig. However, no consistent overview and comparison of pig models of pain are currently available. Therefore, in this review, our primary aim was to identify the available pig models in pain research and compare these models in terms of intensity and duration. First, we systematically searched Proquest, Scopus and Web of Science and compared the duration for which the pigs were significantly sensitized as well as the intensity of mechanical sensitization. We searched models within the specific field of pain and adjacent fields in which pain induction or assessment is relevant, such as pig production. Second, we compared assessment methodologies in surrogate pain models in humans and pigs to identify areas of overlap and possible improvement. Based on the literature search, 23 types of porcine pain models were identified; 13 of which could be compared quantitatively. The induced sensitization lasted from hours to months and intensities ranged from insignificant to the maximum attainable. We also found a near to complete overlap of assessment methodologies between human and pig models within the area of peripheral neurophysiology, which allows for direct comparison of results obtained in the two species. In spite of this overlap, further development of pain assessment methodologies is still needed. We suggest that central nervous system electrophysiology, such as electroencephalography, electrocorticography or intracortical recordings, may pave the way for future objective pain assessment.

将基本的疼痛研究从啮齿动物转化为人类已被证明是一项具有挑战性的任务。已经努力开发临床前大型疼痛动物模型，例如猪。然而，目前还没有关于猪疼痛模型的一致概述和比较。因此，在这篇综述中，我们的主要目的是确定疼痛研究中可用的猪模型，并在强度和持续时间方面比较这些模型。首先，我们系统地搜索了 Proquest、Scopus 和 Web of Science，并比较了猪显着致敏的持续时间以及机械致敏的强度。我们在疼痛的特定领域和与疼痛诱导或评估相关的相邻领域（例如养猪生产）中搜索模型。第二，我们比较了人类和猪的替代疼痛模型中的评估方法，以确定重叠和可能改进的领域。通过文献检索，确定了23种猪疼痛模型；其中13个可以进行定量比较。诱导致敏持续数小时至数月，强度范围从微不足道到最大可达到。我们还发现在周围神经生理学领域内，人类和猪模型之间的评估方法几乎完全重叠，这允许直接比较在两个物种中获得的结果。尽管存在这种重叠，仍然需要进一步开发疼痛评估方法。我们建议中枢神经系统电生理学，如脑电图、皮层电图或皮层内记录，