The Cu-catalyzed oxidative cross-coupling of phenols with methylboronic acid provides a synthetic route to aryl methyl ethers, expanding the scope of Chan-Evans-Lam alkylation. The reaction proceeds under “open flask” conditions with no additional oxidant. Electron-deficient phenol derivatives are methylated in high yields, and some N-heterocycles are tolerated.

中文翻译：

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甲基硼酸的铜催化苯酚 O-甲基化

Cu催化苯酚与甲基硼酸的氧化交叉偶联提供了合成芳基甲基醚的途径，扩大了Chan-Evans-Lam烷基化的范围。反应在“开放烧瓶”条件下进行，无需额外的氧化剂。缺电子苯酚衍生物以高产率被甲基化，并且可以耐受一些 N-杂环。