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Multienzyme nanoassemblies: from rational design to biomedical applications
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-09-18 , DOI: 10.1039/d1bm01106e Di Li 1, 2, 3 , Qirong Xiong 2 , Li Liang 1, 3 , Hongwei Duan 2
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-09-18 , DOI: 10.1039/d1bm01106e Di Li 1, 2, 3 , Qirong Xiong 2 , Li Liang 1, 3 , Hongwei Duan 2
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Multienzyme nanoassemblies (MENAs) that combine the functions of several enzymes into one entity have attracted widespread research interest due to their improved enzymatic performance and great potential for multiple applications. Considerable progress has been made to design and fabricate MENAs in recent years. This review begins with an introduction of the up-to-date strategies in designing MENAs, mainly including substrate channeling, compartmentalization and control of enzyme stoichiometry. The desirable properties that endow MENAs with important applications are also discussed in detail. Then, the recent advances in utilizing MENAs in the biomedical field are reviewed, with a particular focus on biosensing, tumor therapy, antioxidant and drug delivery. Finally, the challenges and perspectives for development of versatile MENAs are summarized.
中文翻译：
多酶纳米组件：从合理设计到生物医学应用
将几种酶的功能结合到一个实体中的多酶纳米组件（MENA）由于其改进的酶促性能和多种应用的巨大潜力而引起了广泛的研究兴趣。近年来，MENA 的设计和制造取得了相当大的进展。本综述首先介绍了设计 MENA 的最新策略，主要包括底物通道、区室化和酶化学计量控制。还详细讨论了赋予 MENA 重要应用的理想特性。然后，回顾了在生物医学领域利用 MENA 的最新进展，特别关注生物传感、肿瘤治疗、抗氧化剂和药物输送。最后，总结了开发多功能 MENA 的挑战和前景。
更新日期：2021-10-14
中文翻译：
多酶纳米组件：从合理设计到生物医学应用
将几种酶的功能结合到一个实体中的多酶纳米组件（MENA）由于其改进的酶促性能和多种应用的巨大潜力而引起了广泛的研究兴趣。近年来，MENA 的设计和制造取得了相当大的进展。本综述首先介绍了设计 MENA 的最新策略，主要包括底物通道、区室化和酶化学计量控制。还详细讨论了赋予 MENA 重要应用的理想特性。然后，回顾了在生物医学领域利用 MENA 的最新进展，特别关注生物传感、肿瘤治疗、抗氧化剂和药物输送。最后，总结了开发多功能 MENA 的挑战和前景。
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