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Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India
Science ( IF 44.7 ) Pub Date : 2021-10-14 , DOI: 10.1126/science.abj9932 Mahesh S Dhar 1 , Robin Marwal 1 , Radhakrishnan Vs 1 , Kalaiarasan Ponnusamy 1 , Bani Jolly 2, 3 , Rahul C Bhoyar 2 , Viren Sardana 2, 3 , Salwa Naushin 2, 3 , Mercy Rophina 2, 3 , Thomas A Mellan 4 , Swapnil Mishra 4 , Charles Whittaker 4 , Saman Fatihi 2, 3 , Meena Datta 1 , Priyanka Singh 1 , Uma Sharma 1 , Rajat Ujjainiya 2, 3 , Nitin Bhatheja 2 , Mohit Kumar Divakar 2, 3 , Manoj K Singh 1 , Mohamed Imran 2, 3 , Vigneshwar Senthivel 2, 3 , Ranjeet Maurya 2, 3 , Neha Jha 2 , Priyanka Mehta 2 , Vivekanand A 2, 3 , Pooja Sharma 2, 3 , Arvinden Vr 2, 3 , Urmila Chaudhary 1 , Namita Soni 1 , Lipi Thukral 2, 3 , Seth Flaxman 5 , Samir Bhatt 4, 6 , Rajesh Pandey 2, 3 , Debasis Dash 2, 3 , Mohammed Faruq 2, 3 , Hemlata Lall 1 , Hema Gogia 1 , Preeti Madan 1 , Sanket Kulkarni 1 , Himanshu Chauhan 1 , Shantanu Sengupta 2, 3 , Sandhya Kabra 1 , , Ravindra K Gupta 7, 8 , Sujeet K Singh 1 , Anurag Agrawal 2, 3 , Partha Rakshit 1 , Vinay Nandicoori , Karthik Bharadwaj Tallapaka , Divya Tej Sowpati , K Thangaraj , Murali Dharan Bashyam , Ashwin Dalal , Sridhar Sivasubbu , Vinod Scaria , Ajay Parida , Sunil K Raghav , Punit Prasad , Apurva Sarin , Satyajit Mayor , Uma Ramakrishnan , Dasaradhi Palakodeti , Aswin Sai Narain Seshasayee , Manoj Bhat , Yogesh Shouche , Ajay Pillai , Tanzin Dikid , Saumitra Das , Arindam Maitra , Sreedhar Chinnaswamy , Nidhan Kumar Biswas , Anita Sudhir Desai , Chitra Pattabiraman , M V Manjunatha , Reeta S Mani , Gautam Arunachal Udupi , Priya Abraham , Potdar Varsha Atul , Sarah S Cherian
Science ( IF 44.7 ) Pub Date : 2021-10-14 , DOI: 10.1126/science.abj9932 Mahesh S Dhar 1 , Robin Marwal 1 , Radhakrishnan Vs 1 , Kalaiarasan Ponnusamy 1 , Bani Jolly 2, 3 , Rahul C Bhoyar 2 , Viren Sardana 2, 3 , Salwa Naushin 2, 3 , Mercy Rophina 2, 3 , Thomas A Mellan 4 , Swapnil Mishra 4 , Charles Whittaker 4 , Saman Fatihi 2, 3 , Meena Datta 1 , Priyanka Singh 1 , Uma Sharma 1 , Rajat Ujjainiya 2, 3 , Nitin Bhatheja 2 , Mohit Kumar Divakar 2, 3 , Manoj K Singh 1 , Mohamed Imran 2, 3 , Vigneshwar Senthivel 2, 3 , Ranjeet Maurya 2, 3 , Neha Jha 2 , Priyanka Mehta 2 , Vivekanand A 2, 3 , Pooja Sharma 2, 3 , Arvinden Vr 2, 3 , Urmila Chaudhary 1 , Namita Soni 1 , Lipi Thukral 2, 3 , Seth Flaxman 5 , Samir Bhatt 4, 6 , Rajesh Pandey 2, 3 , Debasis Dash 2, 3 , Mohammed Faruq 2, 3 , Hemlata Lall 1 , Hema Gogia 1 , Preeti Madan 1 , Sanket Kulkarni 1 , Himanshu Chauhan 1 , Shantanu Sengupta 2, 3 , Sandhya Kabra 1 , , Ravindra K Gupta 7, 8 , Sujeet K Singh 1 , Anurag Agrawal 2, 3 , Partha Rakshit 1 , Vinay Nandicoori , Karthik Bharadwaj Tallapaka , Divya Tej Sowpati , K Thangaraj , Murali Dharan Bashyam , Ashwin Dalal , Sridhar Sivasubbu , Vinod Scaria , Ajay Parida , Sunil K Raghav , Punit Prasad , Apurva Sarin , Satyajit Mayor , Uma Ramakrishnan , Dasaradhi Palakodeti , Aswin Sai Narain Seshasayee , Manoj Bhat , Yogesh Shouche , Ajay Pillai , Tanzin Dikid , Saumitra Das , Arindam Maitra , Sreedhar Chinnaswamy , Nidhan Kumar Biswas , Anita Sudhir Desai , Chitra Pattabiraman , M V Manjunatha , Reeta S Mani , Gautam Arunachal Udupi , Priya Abraham , Potdar Varsha Atul , Sarah S Cherian
Affiliation
Delhi, the national capital of India, has experienced multiple SARS-CoV-2 outbreaks in 2020 and reached population seropositivity of over 50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant B.1.617.2 (Delta) replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates; ×1.5-fold, 20% reduction). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.
中文翻译：
印度德里新出现的 SARS-CoV-2 变种的基因组特征和流行病学
印度首都德里在 2020 年经历了多次 SARS-CoV-2 疫情，到 2021 年人口血清阳性率超过 50%。2021 年 4 月期间，该市因新变种 COVID-19 病例和死亡而不堪重负。 B.1.617.2（Delta）取代了 B.1.1.7（Alpha）。贝叶斯模型解释了 Delta 的生长优势，它通过增加传播性和降低对早期变异产生的免疫反应的敏感性相结合（中值估计；×1.5 倍，减少 20%）。2021 年 3 月至 7 月期间，员工及其家人的血清阳性率从 42% 上升至 87.5%，根据抗体浓度在先前下降后增加判断，再次感染率为 27%。三角洲变种可能具有较高的传播性和部分逃避免疫力，导致德里的病例激增。
更新日期：2021-10-14
中文翻译：
印度德里新出现的 SARS-CoV-2 变种的基因组特征和流行病学
印度首都德里在 2020 年经历了多次 SARS-CoV-2 疫情，到 2021 年人口血清阳性率超过 50%。2021 年 4 月期间，该市因新变种 COVID-19 病例和死亡而不堪重负。 B.1.617.2（Delta）取代了 B.1.1.7（Alpha）。贝叶斯模型解释了 Delta 的生长优势，它通过增加传播性和降低对早期变异产生的免疫反应的敏感性相结合（中值估计；×1.5 倍，减少 20%）。2021 年 3 月至 7 月期间，员工及其家人的血清阳性率从 42% 上升至 87.5%，根据抗体浓度在先前下降后增加判断，再次感染率为 27%。三角洲变种可能具有较高的传播性和部分逃避免疫力，导致德里的病例激增。
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