ABSTRACT

Background

We describe an investigation of temporal trends in the incidence of childhood uveitis-related hospital admissions, hospitalization being a robust indicator of disease severity.

Methods

A population-based retrospective study using a hospitalization database, the Hospital Episode Statistics (HES) dataset, capturing data on care between 2013 and 2020. Primary outcomes were rates of pediatric hospital admissions for uveitis-related disorders.

Results

During the study period, there were 3,258 reported uveitis-related hospital admissions of children aged 0 to 14 years, comprising 19% of all-age uveitis-related admissions. Anterior uveitis was the most common diagnosis. The annual incidence of childhood uveitis-related hospitalizations declined year on year from a peak incidence of 5.4 per 100,000 children (95% confidence interval 5.0–5.9) in 2015–2016 to 3.3 per 100,000 (95% CI 3.0–3.6) in 2019–2020. Over the same period, the national incidence of juvenile arthropathy-related admissions stayed stable.

Conclusion

The decline in admissions nationally may reflect reduced incidence of uveitis complications with increasing use of immunosuppressive therapies.

中文翻译：

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儿童葡萄膜炎的时间趋势：利用行政健康数据调查卫生政策和临床实践的影响

 抽象的

 背景

我们描述了一项对儿童葡萄膜炎相关住院发病率时间趋势的调查，住院治疗是疾病严重程度的有力指标。

 方法

这是一项基于人群的回顾性研究，使用住院数据库、医院发作统计 (HES) 数据集，捕获 2013 年至 2020 年间的护理数据。主要结果是因葡萄膜炎相关疾病的儿科住院率。

 结果

研究期间，有 3,258 名 0 至 14 岁儿童因葡萄膜炎相关入院报告，占所有年龄段葡萄膜炎相关入院人数的 19%。前葡萄膜炎是最常见的诊断。儿童葡萄膜炎相关住院的年发生率逐年下降，从 2015-2016 年每 10 万名儿童 5.4 例（95% 置信区间 5.0-5.9）下降到 2019 年每 10 万名儿童 3.3 例（95% CI 3.0-3.6）。 2020.同期，全国青少年关节病相关入院率保持稳定。

 结论

全国范围内入院人数的下降可能反映出随着免疫抑制疗法的使用增加，葡萄膜炎并发症的发生率降低。