Abstract

In the current study, a new one-dimensional Cu(II) coordination polymer of [Cu(L)(μ-ONO₂)]_n (1) (HL = 4-fluoro-2-(((2-(methylamino)ethyl)imino)methyl)phenol) with bidentate bridging nitrate has been isolated and characterized by X-ray diffraction analysis and elemental analysis. Its application values on the diabetic nephropathy were evaluated and the related mechanism was explored at the same time. First of all, the blood sugar was measured to detect the treatment activity of the new compound. In addition to this, the content of the serum amyloid A and TNF-α was also measured with ELISA detection kit.

中文翻译：

---

一种新的一维铜（II）配位聚合物：晶体结构和对糖尿病肾病的治疗活性

摘要

在目前的研究中，[Cu(L)(μ-ONO ₂ )] _n ( 1 ) (HL = 4-fluoro-2-(((2-(methylamino)乙基）亚氨基）甲基）苯酚）与双齿桥接硝酸盐已被分离并通过 X 射线衍射分析和元素分析表征。评价其在糖尿病肾病中的应用价值，同时探讨其相关机制。首先，通过测量血糖来检测新化合物的治疗活性。除此之外，还用ELISA检测试剂盒测定了血清淀粉样蛋白A和TNF-α的含量。