Rare information is available on fouling behavior of customized nanofiltration (NF) membrane evoked by pharmaceutically active compounds (PhACs) under real multiple influent matrices pretreated by ultrafiltration module beforehand. To this end, a novel tight NF membrane with excellent perm-selectivity and antiadhesion was fabricated and used to assess its separation performance/mechanism and fouling behavior to a broad range of small molecular PhACs in the context. The adsorption ratio results revealed that the affinities between five selected PhACs and the customized nanocomposite membrane surface were all much weaker (below 5.5%) than the solute-solute interacting forces (between 23.6 and 83.2%), whether for natural or synthetic complex micropollutants. The predominant membrane fouling could be interpreted by the incomplete blocking model in the permeation of both influent conditions. For neat nanocomposite membrane, the order of critical factors important on separation mechanism was electrostatic effect, adsorption and steric hindrance. The fouling layer seemed to act as a secondary separating layer for those negatively charged or hydrophilic PhACs, but showed the cake enhanced concentration polarization effect for the neutral and hydrophobic ones. This study provides valuable insights for defining PhACs fate and NF membrane fouling behavior to fit increasingly stringent criteria for wastewater treatment.

关于由药物活性化合物 (PhAC) 引起的定制纳滤 (NF) 膜在预先通过超滤模块预处理的真实多进水基质下的污染行为的信息很少。为此，制造了一种具有优异渗透选择性和抗粘附性的新型紧密 NF 膜，并用于评估其分离性能/机制以及对范围广泛的小分子 PhAC 的污染行为。吸附率结果表明，无论是对于天然还是合成的复杂微污染物，五种选定的 PhAC 与定制纳米复合膜表面之间的亲和力都比溶质 - 溶质相互作用力（23.6 至 83.2%）弱得多（低于 5.5%）。主要的膜污染可以通过两种进水条件渗透中的不完全阻塞模型来解释。对于纯纳米复合膜，对分离机制重要的关键因素的顺序是静电效应、吸附和位阻。污垢层似乎充当那些带负电或亲水性 PhAC 的辅助分离层，但显示出饼增强了中性和疏水性 PhAC 的浓差极化效应。这项研究为定义 PhAC 归宿和 NF 膜污染行为提供了宝贵的见解，以适应日益严格的废水处理标准。吸附和位阻。污垢层似乎充当那些带负电或亲水性 PhAC 的辅助分离层，但显示出饼增强了中性和疏水性 PhAC 的浓差极化效应。这项研究为定义 PhAC 归宿和 NF 膜污染行为提供了宝贵的见解，以适应日益严格的废水处理标准。吸附和位阻。污垢层似乎充当那些带负电或亲水性 PhAC 的辅助分离层，但显示出饼增强了中性和疏水性 PhAC 的浓差极化效应。这项研究为定义 PhAC 归宿和 NF 膜污染行为提供了宝贵的见解，以适应日益严格的废水处理标准。