A form of adenine base editing has been used in mouse embryos to correct a genetic variant associated with hypertrophic cardiomyopathy. This approach is potentially safer than other forms of germline gene editing, which carry a risk of off-target editing and the introduction of indels.

中文翻译：

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小鼠胚胎中的腺嘌呤碱基编辑以纠正 HCM

一种形式的腺嘌呤碱基编辑已被用于小鼠胚胎，以纠正与肥厚型心肌病相关的遗传变异。这种方法可能比其他形式的种系基因编辑更安全，后者存在脱靶编辑和引入插入缺失的风险。