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dNTPpoolDB: a manually curated database of experimentally determined dNTP pools and pool changes in biological samples
Nucleic Acids Research ( IF 16.6 ) Pub Date : 2021-09-30 , DOI: 10.1093/nar/gkab910
Rita Pancsa 1 , Erzsébet Fichó 1, 2 , Dániel Molnár 1 , Éva Viola Surányi 1 , Tamás Trombitás 1 , Dóra Füzesi 1 , Hanna Lóczi 1 , Péter Szijjártó 1 , Rita Hirmondó 1 , Judit E Szabó 1 , Judit Tóth 1, 3
Affiliation  

Stimulated by the growing interest in the role of dNTP pools in physiological and malignant processes, we established dNTPpoolDB, the database that offers access to quantitative data on dNTP pools from a wide range of species, experimental and developmental conditions (https://dntppool.org/). The database includes measured absolute or relative cellular levels of the four canonical building blocks of DNA and of exotic dNTPs, as well. In addition to the measured quantity, dNTPpoolDB contains ample information on sample source, dNTP quantitation methods and experimental conditions including any treatments and genetic manipulations. Functions such as the advanced search offering multiple choices from custom-built controlled vocabularies in 15 categories in parallel, the pairwise comparison of any chosen pools, and control-treatment correlations provide users with the possibility to quickly recognize and graphically analyse changes in the dNTP pools in function of a chosen parameter. Unbalanced dNTP pools, as well as the balanced accumulation or depletion of all four dNTPs result in genomic instability. Accordingly, key roles of dNTP pool homeostasis have been demonstrated in cancer progression, development, ageing and viral infections among others. dNTPpoolDB is designated to promote research in these fields and fills a longstanding gap in genome metabolism research.

中文翻译:

dNTPpoolDB:一个手动管理的数据库,包含实验确定的 dNTP 池和生物样本中的池变化

由于人们对 dNTP 池在生理和恶性过程中的作用越来越感兴趣,我们建立了 dNTPpoolDB,该数据库提供了对来自各种物种、实验和发育条件的 dNTP 池的定量数据的访问(https://dntppool.组织/)。该数据库还包括测量的四种典型 DNA 构建块和外来 dNTPs 的绝对或相对细胞水平。除了测量的数量外,dNTPpoolDB 还包含有关样本来源、dNTP 定量方法和实验条件(包括任何处理和基因操作)的大量信息。高级搜索等功能可从 15 个并行类别的自定义受控词汇表中提供多种选择,任何选定库的成对比较,和控制-治疗相关性为用户提供了快速识别和图形分析 dNTP 池在所选参数函数中的变化的可能性。不平衡的 dNTP 池以及所有四种 dNTP 的平衡积累或消耗导致基因组不稳定。因此,dNTP 池稳态的关键作用已在癌症进展、发展、衰老和病毒感染等方面得到证实。dNTPpoolDB 旨在促进这些领域的研究,填补了基因组代谢研究中长期存在的空白。dNTP 池稳态的关键作用已在癌症进展、发展、衰老和病毒感染等方面得到证实。dNTPpoolDB 旨在促进这些领域的研究,填补了基因组代谢研究中长期存在的空白。dNTP 池稳态的关键作用已在癌症进展、发展、衰老和病毒感染等方面得到证实。dNTPpoolDB 旨在促进这些领域的研究,填补了基因组代谢研究中长期存在的空白。
更新日期:2021-09-30
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