Abstract Background There is a transition from wire-guided localization (WGL) of non-palpable breast cancer to other localization techniques. Multiple prospective studies have sought to establish superior clinical outcomes for radioactive-seed localization (RSL), but consistent and congruent evidence is missing. Methods In this study, female patients with breast cancer operated with breast-conserving surgery after tumour localization of a non-palpable breast cancer or ductal carcinoma in situ (DCIS) were included. The cohort was identified from the nationwide Netherlands Breast Cancer Audit conducted between 2013 and 2018. Trends in localization techniques were analysed. Univariable and multivariable analyses were performed to assess the association between the localization technique and the probability of a reoperation. Results A total of 28 370 patients were included in the study cohort. The use of RSL increased from 15.7 to 61.1 per cent during the study years, while WGL decreased from 75.4 to 31.6 per cent. The localization technique used (RSL versus WGL) was not significantly associated with the odds of a reoperation, regardless of whether the lesion was DCIS (odds ratio 0.96 (95 per cent c.i. 0.89 to 1.03; P = 0.281)) or invasive breast cancer (OR 1.02 (95 per cent c.i. 0.96 to 1.10; P = 0.518)). Conclusion RSL is rapidly replacing WGL as the preoperative localization technique in breast surgery. This large nationwide registry study found no association between the type of localization technique and the odds of having a reoperation, thus confirming the results of previous prospective cohort studies.

中文翻译：

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关于不可触及导管原位癌和浸润性乳腺癌定位技术和再手术率趋势的全国注册研究

摘要 背景不可触及乳腺癌的线引导定位 (WGL) 正在转变为其他定位技术。多项前瞻性研究试图建立放射性粒子定位（RSL）的卓越临床结果，但缺乏一致和一致的证据。 方法在这项研究中，纳入了在肿瘤定位为不可触及的乳腺癌或导管原位癌（DCIS）后接受保乳手术的女性乳腺癌患者。该队列是从 2013 年至 2018 年期间进行的荷兰全国乳腺癌审计中确定的。分析了定位技术的趋势。进行单变量和多变量分析以评估定位技术与再次手术概率之间的关联。 结果该研究队列共有 28 370 名患者。在研究期间，RSL 的使用率从 15.7% 增加到 61.1%，而 WGL 的使用率从 75.4% 下降到 31.6%。无论病变是 DCIS（比值比 0.96（95% CI 0.89 至 1.03；P = 0.281））还是浸润性乳腺癌（RSL 与 WGL），所使用的定位技术（RSL 与 WGL）与再次手术的几率没有显着相关。 OR 1.02（95% CI 0.96 至 1.10；P = 0.518））。 结论RSL 正在迅速取代 WGL 作为乳腺手术的术前定位技术。这项大型全国性登记研究发现定位技术的类型与再次手术的几率之间没有关联，从而证实了之前的前瞻性队列研究的结果。