Abstract

Previous studies report hippocampal volume loss can help predict conversion from normative aging to mild cognitive impairment (MCI) to dementia. Additionally, a growing literature indicates that stress-related allostatic load may increase disease vulnerability. The current study examined the relationship between stress related cytokines (i.e., interleukin-6 - IL-6), cognition as measured by Mini Mental Status scores (MMSE), and hippocampal volume. Mixed-models were employed to examine both within (across time) and between subjects effects of IL-6 and hippocampal volume on MMSE score among 566 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). The within subjects analysis found left hippocampal volume significantly (p= .009) predicted MMSE score. Between subjects analysis found the effect of IL-6 on MMSE was moderated by right hippocampal volume (p = .001). These results replicate previous findings and also extend prior work demonstrating stress-related cytokines may play a role in Alzheimer’s disease (AD) progression.

中文翻译：

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白细胞介素 6 与海马体积之间关联的混合效应模型

摘要

先前的研究报告称，海马体积减少有助于预测从正常衰老到轻度认知障碍 (MCI) 到痴呆的转变。此外，越来越多的文献表明，与压力相关的异压负荷可能会增加疾病的易感性。目前的研究检查了压力相关细胞因子（即白细胞介素6-IL-6）、通过最小精神状态评分（MMSE）测量的认知和海马体积之间的关系。在阿尔茨海默病神经影像学倡议 (ADNI) 的 566 名参与者中，使用混合模型来检查 IL-6 和海马体积对 MMSE 评分的内部（跨时间）和受试者之间的影响。受试者内部分析发现左侧海马体积显着 (p= .009) 可预测 MMSE 评分。受试者之间的分析发现，IL-6 对 MMSE 的影响受到右侧海马体积的调节（p = .001）。这些结果复制了先前的发现，并扩展了先前的工作，证明与压力相关的细胞因子可能在阿尔茨海默病 (AD) 的进展中发挥作用。