Coating of nanoscale flow aids is widely used in pharmaceutical applications to increase the flowability of cohesive powders. For combustible pharmaceutical active ingredients and excipients, it is unclear whether increased flowability affects the dust explosion hazard. In this work, acetaminophen (APAP) and microcrystalline cellulose (MCC) were studied with and without a coating of silica nanoparticles. A full set of explosion parameters for the pure materials and their flow-improved mixtures was determined in accordance with ASTM standards. The results show that parameters including minimum ignition temperature, minimum explosible concentration, and maximum explosion pressure were independent of powder flow properties, while the presence of flow aids led to significantly lower minimum ignition energy values for both APAP and MCC, and a slightly higher maximum rate of pressure rise for APAP. The connection between dust flowability and the dust explosion hazard is discussed with respect to these experimental results.

纳米级流动助剂的涂层广泛用于制药应用，以增加粘性粉末的流动性。对于可燃药物活性成分和赋形剂，流动性增加是否会影响粉尘爆炸危险尚不清楚。在这项工作中，研究了对乙酰氨基酚 (APAP) 和微晶纤维素 (MCC) 有和没有二氧化硅纳米粒子涂层。纯材料及其流动改进混合物的全套爆炸参数是根据 ASTM 标准确定的。结果表明，包括最低点火温度、最低爆炸浓度和最高爆炸压力在内的参数与粉末流动特性无关，而助流剂的存在导致 APAP 和 MCC 的最低点火能量值显着降低，APAP 的最大压力上升速率略高。根据这些实验结果讨论了粉尘流动性和粉尘爆炸危险之间的联系。