ABSTRACT

Purpose

Herpes zoster ophthalmicus (HZO) is traditionally considered as an unilateral disease. However, subclinical involvements in the contralateral eye structures are evidence, giving rise to a broader understanding of varicella-zoster virus (VZV) infection.

Methods

We enrolled 20 eyes of 10 patients with HZO and 12 eyes of healthy controls to investigate the bilateral features of HZO patients using a hand-held pupillometer and a Cochet-Bonnet esthesiometer.

Results

Maximum pupil size before constriction (INT) and minimum diameter when pupil constricts at peak (END) were significantly smaller in patients affected eyes compared with those in controls (p < .05). Interestingly, INT and END were significantly reduced in contralateral eyes of 20 affected patients and also in comparison to control group (p < .001 and p = .034 respectively).

Conclusion

The contralateral eyes may have subclinical involvement in patients with HZO based on significantly abnormal pupillary light reflex (PLR). Pupillometer provides a primary and convenient method to investigate the anatomy and pathology of the PLR

中文翻译：

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双侧瞳孔受累作为眼部带状疱疹的临床表现

摘要

目的

带状疱疹眼科 (HZO) 传统上被认为是一种单侧疾病。然而，对侧眼结构的亚临床受累是证据，使人们对水痘-带状疱疹病毒 (VZV) 感染有了更广泛的了解。

方法

我们招募了 10 名 HZO 患者的 20 只眼和健康对照者的 12 只眼，以使用手持式瞳孔计和 Cochet-Bonnet 感觉计调查 HZO 患者的双侧特征。

结果

与对照组相比，受影响的眼睛在收缩前的最大瞳孔大小 (INT) 和瞳孔收缩峰值 (END) 时的最小直径明显较小 (p < .05)。有趣的是，与对照组相比，20 名受影响患者的对侧眼的 INT 和 END 显着降低（分别为 p < .001 和 p = .034）。

结论

基于显着异常的瞳孔光反射 (PLR)，HZO 患者的对侧眼可能有亚临床受累。瞳孔计提供了一种主要且方便的方法来研究 PLR 的解剖学和病理学