Objective

To evaluate visual acuity (VA) and factors influencing VA using new multimodal imaging-based classification of central serous chorioretinopathy (CSCR).

Methods

Retrospective, observational and cross-sectional study on 229 naïve eyes diagnosed as CSCR with available baseline data and multimodal imaging. Each case was classified into (i) simple/complex/atypical; (ii) primary/recurrent/resolved; (iii) persistent or not; (iv) outer retinal atrophy(ORA) present/absent; (v) foveal involvement present/absent; and (vi) macular neovascularization(MNV) present/absent. Best corrected visual acuity (BCVA) was correlated to the classification as well as every parameter of the classification.

Results

Median BCVA was 0.18 logMAR [95% Confidence Interval (CI)0.16–0.18] with median duration of complaints of one month (95% CI,6.14–13.0 months). Age of the patient (r = −0.24, p = 0.002) and duration of the disease (r = −0.32, p < 0.001) correlated significantly with BCVA. Logistic regression model showed that older age [odds ratio (OR) = 0.96, p = 0.05], female gender (OR = 2.45, p = 0.046), presence of ORA(OR = 0.34, p = 0.012),and foveal involvement(OR = 0.18, p = 0.007) were statistically significantly associated with poorer BCVA. Eyes classified as complex, persistent CSCR, with ORA or foveal involvement demonstrated lower BCVA compared to those with simple, non-persistent CSCR, without ORA or without foveal involvement (p < 0.05). Eyes with complex CSCR (p < 0.001), atypical CSCR(p = 0.025), persistent subretinal fluid (SRF) (p = 0.001) and those with ORA (p < 0.001) demonstrated a trend towards severe visual loss. Prevalence of persistent SRF, recurrent episodes and ORA was significantly higher among eyes with complex CSCR (p < 0.001) while there was no difference in prevalence of resolved cases (p = 0.07), foveal involvement (p = 0.28) and MNV (p = 0.45) between simple and complex cases.

Conclusion

There is a strong correlation between VA and foveal involvement and ORA using the new classification. Thus, the objective parameters of the classification can be incorporated in establishing the treatment guidelines for CSCR.

中文翻译：

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视力与基于多模态成像的中心性浆液性脉络膜视网膜病变类别相关

客观的

使用新的基于多模式成像的中心性浆液性脉络膜视网膜病变 (CSCR) 分类评估视力 (VA) 和影响 VA 的因素。

方法

使用可用的基线数据和多模态成像对 229 只被诊断为 CSCR 的幼稚眼进行回顾性、观察性和横断面研究。每个病例被分为（i）简单/复杂/非典型；(ii) 初级/经常性/已解决；(iii) 持续与否；(iv) 外层视网膜萎缩 (ORA) 存在/不存在；(v) 中心凹受累存在/不存在；(vi) 黄斑新生血管 (MNV) 存在/不存在。最佳矫正视力 (BCVA) 与分类以及分类的每个参数相关。

结果

BCVA 中位数为 0.18 logMAR [95% 置信区间 (CI)0.16–0.18]，投诉持续时间中位数为 1 个月（95% CI，6.14–13.0 个月）。患者年龄 ( r  = -0.24, p  = 0.002) 和病程 ( r  = -0.32, p  < 0.001) 与 BCVA 显着相关。Logistic 回归模型显示年龄较大 [比值比 (OR) = 0.96，p  = 0.05]，女性（OR = 2.45，p  = 0.046），存在 ORA（OR = 0.34，p  = 0.012）和中心凹受累（或者 = 0.18，p = 0.007) 与较差的 BCVA 在统计学上显着相关。与简单、非持续性 CSCR、无 ORA 或无中心凹受累的眼睛相比，被归类为复杂、持续性 CSCR、ORA 或中心凹受累的眼睛的 BCVA 较低 (p < 0.05 )  。复杂 CSCR ( p  < 0.001)、非典型 CSCR (p = 0.025)、持续性视网膜下积液 (SRF) ( p  = 0.001) 和 ORA ( p  < 0.001) 的眼睛表现出严重视力丧失的趋势。持续性 SRF、复发发作和 ORA 的患病率在具有复杂 CSCR 的眼睛中显着更高 ( p  < 0.001)，而在解决病例 ( p  = 0.07)、中心凹受累 (p  = 0.28) 和 MNV ( p  = 0.45) 在简单和复杂情况之间。

结论

使用新分类，VA 和中心凹受累与 ORA 之间存在很强的相关性。因此，分类的客观参数可以纳入 CSCR 治疗指南的制定中。