Purpose

To evaluate the prevalence of the obstruction of lacrimal drainage system (LDS) in patients with pseudoexfoliation (PXF) syndrome.

Materials and Methods

This cross-sectional study included 152 eyes of 76 consecutive patients with bilateral PXF syndrome and 170 eyes of 85 age and gender-matched controls. The LDS evaluation was performed based on dye disappearance test, slit-lamp examination, diagnostic probing, and irrigation test. The presence of punctal stenosis and canalicular obstruction were considered as the obstruction of proximal LDS; and complete or incomplete nasolacrimal duct obstruction was considered as obstruction of distal LDS. Demographic characteristics, ophthalmologic findings, and prevalence and site of obstruction of LDS were compared among the groups.

Results

The prevalence of obstruction of LDS was higher in the PXF syndrome group when compared to controls (21.1% vs 12.2%), but the difference was not statistically significant (p = 0.061). The obstruction of proximal LDS was found to be more frequent in the PXF syndrome (17.7%) group when compared to controls (10.0%), and this difference was statistically significant (p = 0.041). There was significantly more punctal stenosis in the PXF syndrome group when compared to controls (15.1% vs 7.6%, p = 0.033). The prevalence of canalicular stenosis and obstruction of distal LDS was similar in the PXF and the control groups (p = 0.596 and p = 0.741, respectively).

Conclusion

The prevalence of punctal stenosis was statistically significantly higher in the PXF syndrome group when compared to the controls. This association is probably related to increased local ocular surface inflammation which is triggered by the accumulation of PXF material.

中文翻译：

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假性剥脱综合征泪道引流系统的评价

目的

评估假性剥脱 (PXF) 综合征患者泪道引流系统 (LDS) 阻塞的患病率。

材料和方法

这项横断面研究包括 76 名双侧 PXF 综合征患者的 152 只眼和 85 名年龄和性别匹配的对照组的 170 只眼。LDS 评估基于染料消失试验、裂隙灯检查、诊断性探查和冲洗试验进行。泪点狭窄和小管阻塞的存在被认为是近端LDS的阻塞；鼻泪管完全或不完全阻塞被认为是远端LDS阻塞。比较各组之间的人口统计学特征、眼科检查结果、LDS 的患病率和梗阻部位。

结果

与对照组相比，PXF 综合征组 LDS 梗阻的发生率更高（21.1% vs 12.2%），但差异无统计学意义（p  = 0.061）。与对照组 (10.0%) 相比，PXF 综合征组 (17.7%) 的近端 LDS 阻塞更常见，并且这种差异具有统计学意义 ( p  = 0.041)。与对照组相比，PXF 综合征组的泪点狭窄明显更多（15.1% 对 7.6%，p  = 0.033）。PXF 组和对照组的小管狭窄和远端 LDS 阻塞的发生率相似（分别为p  = 0.596 和p  = 0.741）。

结论

与对照组相比，PXF 综合征组泪点狭窄的患病率在统计学上显着升高。这种关联可能与由 PXF 物质的积累引发的局部眼表炎症增加有关。