Direct Access to Unique C-5’-Acyl Modified Nucleosides through Liebeskind–Srogl Cross-Coupling Reaction,European Journal of Organic Chemistry

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Direct Access to Unique C-5’-Acyl Modified Nucleosides through Liebeskind–Srogl Cross-Coupling Reaction
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-10-13 , DOI: 10.1002/ejoc.202101061
Mary Anne Maverick ₁ , Marie Gaillard ₂ , Jean-Jacques Vasseur ₂ , Françoise Debart ₂ , Michael Smietana ₃

Affiliation

An efficient palladium/CuTC cocatalyzed cross-coupling reaction procedure for the synthesis of C-5’-acyl nucleosides from the corresponding nucleoside 5′-carbothioates and boronic acids is described. The procedure is fast, efficient, and it tolerates a wide variety of functionalities, thus expanding the so far limited chemical methods for C-5’ diversification of deoxy- and ribonucleosides.

中文翻译：

通过 Liebeskind-Srogl 交叉偶联反应直接获得独特的 C-5'-酰基修饰核苷

描述了一种有效的钯/CuTC 共催化交叉偶联反应程序，用于从相应的核苷 5'-硫代硫代糖酸酯和硼酸合成 C-5'-酰基核苷。该程序快速、高效，并且具有多种功能，从而扩展了迄今为止有限的 C-5' 脱氧和核糖核苷多样化的化学方法。

更新日期：2021-10-13

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