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Direct Access to Unique C-5’-Acyl Modified Nucleosides through Liebeskind–Srogl Cross-Coupling Reaction
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2021-10-13 , DOI: 10.1002/ejoc.202101061
Mary Anne Maverick 1 , Marie Gaillard 2 , Jean-Jacques Vasseur 2 , Françoise Debart 2 , Michael Smietana 3
Affiliation  

An efficient palladium/CuTC cocatalyzed cross-coupling reaction procedure for the synthesis of C-5’-acyl nucleosides from the corresponding nucleoside 5′-carbothioates and boronic acids is described. The procedure is fast, efficient, and it tolerates a wide variety of functionalities, thus expanding the so far limited chemical methods for C-5’ diversification of deoxy- and ribonucleosides.

中文翻译:

通过 Liebeskind-Srogl 交叉偶联反应直接获得独特的 C-5'-酰基修饰核苷

描述了一种有效的钯/CuTC 共催化交叉偶联反应程序,用于从相应的核苷 5'-硫代硫代糖酸酯和硼酸合成 C-5'-酰基核苷。该程序快速、高效,并且具有多种功能,从而扩展了迄今为止有限的 C-5' 脱氧和核糖核苷多样化的化学方法。
更新日期:2021-10-13
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