In Reply We would like to thank Aini et al for commenting on our article on liver transplant (LT) in colorectal cancer liver metastases. Our results were presented as Kaplan-Maier–estimated overall survival (OS) because not all patients were observed for 5 years or until death. According to Aini et al, patients receiving portal vein embolization (PVE) and liver resection (LR) had a 5-year OS of 54.8% compared with 50.0% in patients receiving LT, which lead Aini et al to conclude that LT does not result in better OS than PVE-LR. For the PVE-LR and LT groups, patients with low tumor load had significantly better OS than patients with high tumor load. As reported in the PVE-LR group, 5-year OS was 69.3% (n = 23) and 12.5% (n = 8) in the groups with low tumor load vs high tumor load, respectively. In the LT group, the results were 72.4% and 33.4% for the groups with low tumor load vs high tumor load, respectively. In the PVE-LR (high tumor load and low tumor load) cohorts, 8 of 31 patients (25.8%) had high tumor load. In contrast, in the LT group, 29 of 50 patients (58.0%) were in the high tumor load category. This critical difference in the tumor load is not taken into account when Aini et al did the calculations, and their statement is therefore misleading.

中文翻译：

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大肠癌肝转移肝移植尚无有力证据——回复

作为回复，我们要感谢 Aini 等人对我们关于结直肠癌肝转移的肝移植 (LT) 的文章发表评论。我们的结果以 Kaplan-Maier 估计的总生存期 (OS) 呈现，因为并非所有患者都被观察 5 年或直至死亡。根据 Aini 等人，接受门静脉栓塞术 (PVE) 和肝切除术 (LR) 的患者的 5 年 OS 为 54.8%，而接受 LT 的患者为 50.0%，这导致 Aini 等人得出结论，LT 不会导致在比 PVE-LR 更好的操作系统中。对于 PVE-LR 和 LT 组，低肿瘤负荷患者的 OS 显着优于高肿瘤负荷患者。正如 PVE-LR 组报道的那样，低肿瘤负荷组和高肿瘤负荷组的 5 年 OS 分别为 69.3% (n = 23) 和 12.5% (n = 8)。在 LT 组中，结果分别为 72.4% 和 33。低肿瘤负荷组和高肿瘤负荷组分别为 4%。在 PVE-LR（高肿瘤负荷和低肿瘤负荷）队列中，31 名患者中有 8 名（25.8%）具有高肿瘤负荷。相比之下，在 LT 组中，50 名患者中有 29 名 (58.0%) 属于高肿瘤负荷类别。当 Aini 等人进行计算时，没有考虑到肿瘤负荷的这种关键差异，因此他们的说法具有误导性。