Understanding how nutrient-sensitive signaling pathways regulate development and aging is an active area of research. In this issue of Developmental Cell, Zhu and colleagues (2021) identify a specific monomethylated branched-chain fatty acid that overrides nutrient deprivation signaling and activates mTORC1 in C. elegans and mammalian cells.

中文翻译：

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亮氨酸衍生脂肪酸解锁 mTOR 的发育

了解营养敏感信号通路如何调节发育和衰老是一个活跃的研究领域。在本期《发育细胞》中， Zhu 及其同事 (2021) 鉴定了一种特定的单甲基化支链脂肪酸，它可以克服营养剥夺信号并激活秀丽隐杆线虫和哺乳动物细胞中的 mTORC1。