Emerging infectious diseases significantly threaten global public health and socioeconomic security. The majority of emerging infectious disease outbreaks are caused by zoonotic/vector-borne viruses. Bats and rodents are the two most important reservoir hosts of many zoonotic viruses that can cross species barriers to infect humans, whereas mosquitos and ticks are well-established major vectors of many arboviral diseases. Moreover, some emerging zoonotic diseases require a vector to spread or are intrinsically vector-borne and zoonotically transmitted. In this study, we present a newly upgraded database of zoonotic and vector-borne viruses designated ZOVER (http://www.mgc.ac.cn/ZOVER). It incorporates two previously released databases, DBatVir and DRodVir, for bat- and rodent-associated viruses, respectively, and further collects up-to-date knowledge on mosquito- and tick-associated viruses to establish a comprehensive online resource for zoonotic and vector-borne viruses. Additionally, it integrates a set of online visualization tools for convenient comparative analyses to facilitate the discovery of potential patterns of virome diversity and ecological characteristics between/within different viral hosts/vectors. The ZOVER database will be a valuable resource for virologists, zoologists and epidemiologists to better understand the diversity and dynamics of zoonotic and vector-borne viruses and conduct effective surveillance to monitor potential interspecies spillover for efficient prevention and control of future emerging zoonotic diseases.

中文翻译：

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ZOVER：人畜共患病和媒介传播病毒数据库

新出现的传染病严重威胁着全球公共卫生和社会经济安全。大多数新出现的传染病暴发是由人畜共患病/媒介传播的病毒引起的。蝙蝠和啮齿动物是许多人畜共患病病毒的两个最重要的宿主，它们可以跨越物种障碍感染人类，而蚊子和蜱虫是许多虫媒病毒疾病的公认主要载体。此外，一些新出现的人畜共患病需要媒介来传播，或者本质上是媒介传播的和人畜共患病传播的。在这项研究中，我们提出了一个新升级的人畜共患病和媒介传播病毒数据库，命名为 ZOVER (http://www.mgc.ac.cn/ZOVER)。它包含两个先前发布的数据库 DBatVir 和 DRodVir，分别用于蝙蝠和啮齿动物相关病毒，并进一步收集有关蚊子和蜱相关病毒的最新知识，以建立人畜共患病和媒介传播病毒的综合在线资源。此外，它还集成了一组在线可视化工具，便于进行比较分析，以促进发现不同病毒宿主/载体之间/内部的病毒组多样性和生态特征的潜在模式。ZOVER 数据库将成为病毒学家、动物学家和流行病学家的宝贵资源，以更好地了解人畜共患病和媒介传播病毒的多样性和动态，并进行有效监测以监测潜在的种间溢出，从而有效预防和控制未来新出现的人畜共患病。