The effect of subretinal fluid (SRF) in uveitic cystoid macular edema (CME) is not fully understood. This study evaluates the quantitative effect of SRF and intraretinal thickness on visual acuity in eyes with uveitic CME. We separately measured SRF and intraretinal area on Optical Coherence Tomography (OCT) to determine the associations of each component with visual acuity and response to treatment. Medical records were reviewed of patients with CME presenting to the University of Colorado uveitis clinic from January 2012 to May 2019. All available OCTs were reviewed to classify eyes as either having only CME or CME with SRF. Intraretinal area was manually measured using Image J along the central 1-mm section of B-scan OCT spanning from the internal limiting membrane to the outer most portion of the outer retina including both cysts and retinal tissue. SRF cross-sectional area was measured spanning from the outermost portion of the outer retina to retinal pigment epithelium. Response to treatment was assessed one to four months after presentation. Eyes with CME secondary to structural or non-inflammatory causes were excluded. Forty-seven (50.5%) eyes had CME alone and 46 (49.5%) eyes had SRF with CME. Measured SRF cross-sectional area was not associated (p = 0.21) with LogMAR at presentation. Conversely, intraretinal area was strongly correlated with visual acuity in eyes with SRF (p < 0.001) and without SRF (p < 0.001). Following treatment, there was a significant decrease in intraretinal area for both groups (p < 0.001), with a larger decrease in the SRF group compared to the non-SRF group (p = 0.001). Similarly, logMAR improved in both groups (p = 0.008 for SRF eyes and p = 0.005 for non-SRF eyes), but the change was more prominent in the SRF group (p = 0.06). There was no direct association observed between the amount of SRF and visual acuity. In contrast, increased intraretinal area was significantly associated with decreased visual acuity. This relationship between intraretinal thickening and visual acuity may explain differences observed in response to treatment between SRF and non-SRF eyes, with a larger decrease in the intraretinal cross-sectional area in SRF eyes associated with a greater improvement in logMAR visual acuity.

中文翻译：

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视网膜下液和视网膜内水肿对葡萄膜炎性黄斑囊样水肿视力的定量影响

视网膜下液 (SRF) 在葡萄膜炎性黄斑囊样水肿 (CME) 中的作用尚不完全清楚。本研究评估 SRF 和视网膜内厚度对葡萄膜炎 CME 眼睛视力的定量影响。我们分别测量了光学相干断层扫描 (OCT) 上的 SRF 和视网膜内面积，以确定每个组件与视力和对治疗的反应的关联。审查了 2012 年 1 月至 2019 年 5 月在科罗拉多大学葡萄膜炎诊所就诊的 CME 患者的医疗记录。审查了所有可用的 OCT，以将眼睛分类为只有 CME 或 CME 与 SRF。使用 Image J 沿 B 扫描 OCT 的中央 1 mm 部分手动测量视网膜内区域，从内界膜到包括囊肿和视网膜组织在内的外视网膜最外层部分。测量从外层视网膜最外层到视网膜色素上皮的 SRF 横截面积。在就诊后一到四个月评估对治疗的反应。继发于结构性或非炎症性原因的 CME 眼睛被排除在外。47 只（50.5%）只眼有 CME，46 只（49.5%）只眼有 SRF 和 CME。测量的 SRF 横截面积与呈现时的 LogMAR 无关（p = 0.21）。相反，视网膜内面积与有 SRF (p < 0.001) 和没有 SRF (p < 0.001) 的眼睛的视力密切相关。治疗后，两组的视网膜内面积均显着减少（p < 0.001），与非 SRF 组相比，SRF 组的减少幅度更大（p = 0.001）。同样，两组的 logMAR 均有所改善（SRF 眼 p = 0.008，非 SRF 眼 p = 0.005），但 SRF 组的变化更为显着（p = 0.06）。没有观察到 SRF 量和视力之间的直接关联。相反，视网膜内面积增加与视力下降显着相关。视网膜内增厚和视力之间的这种关系可以解释在 SRF 和非 SRF 眼睛之间对治疗的反应所观察到的差异，SRF 眼睛中视网膜内横截面积的更大减少与 logMAR 视力的更大改善相关。