Purpose

To compare the progression rate and time to progression determined using the Belin ABCD Progression Display (BAPD) with conventional metrics in patients with keratoconus (KC).

Design

Retrospective comparison of progression assessment.

Methods

Patients 18 years and older and 35 years and younger with at least 1 year of follow-up and 3 Pentacam (Oculus, Inc) visits were included in the study. Progression was evaluated by selecting either the first visit or the first 2 visits individually as the baseline on the BAPD, and the red gate was used to determine progression (variability in any A, B, and C parameters ≥95% CI or any 2 parameters ≥80% CI). An increase of ≥1 diopter in corneal astigmatism and curvature parameters and a ≥2% reduction in thickness parameters constituted progressive disease.

Results

Two hundred seventy-seven eyes of 155 patients were included. The 2 baseline visit criteria identified the highest progression (n = 186 [67.2%]), followed by the single baseline visit (n = 158 [57%]), minimum corneal thickness (n = 114 [41.2%]), central corneal thickness (n = 111 [40.1%]), maximum keratometry (n = 76 [27.4%]), corneal astigmatism (n = 55 [19.9%]), back mean keratometry (n = 50 [18.1%]), and front mean keratometry (n = 31 [11.2%]) criteria. The median time to progression was shortest using the single baseline visit criterion (11 months), followed by the 2 baseline visits (11.6 months), minimum corneal thickness (12.1 months), maximum keratometry (12.3 months), corneal astigmatism (14.8 months), central corneal thickness (16.6 months), back mean keratometry (18.4 months), and front mean keratometry (24.4 months) criteria. In a subgroup analysis, progression could be identified 4 to 7 months earlier with the BAPD in eyes that were also progressive for maximum keratometry and central corneal thickness.

Conclusions

BAPD detects progression at a higher rate and earlier than conventional parameters.

中文翻译：

---

Belin ABCD 进展显示比传统指标更早地识别圆锥角膜进展

目的

比较使用 Belin ABCD 进展显示 (BAPD) 确定的进展率和进展时间与圆锥角膜 (KC) 患者的常规指标。

设计

进展评估的回顾性比较。

方法

该研究包括 18 岁及以上和 35 岁及以下的患者，至少有 1 年的随访和 3 次 Pentacam (Oculus, Inc) 就诊。通过分别选择第一次访问或前 2 次访问作为 BAPD 的基线来评估进展，红色门用于确定进展（任何 A、B 和 C 参数的变异性≥95% CI 或任何 2 个参数≥80% CI）。角膜散光和曲率参数增加≥1屈光度以及厚度参数减少≥2%构成进行性疾病。

结果

纳入 155 名患者的 277 只眼。2 次基线访问标准确定了最高进展（n = 186 [67.2%]），其次是单次基线访问（n = 158 [57%]）、最小角膜厚度（n = 114 [41.2%]）、中央角膜厚度 (n = 111 [40.1%])、最大角膜曲率 (n = 76 [27.4%])、角膜散光 (n = 55 [19.9%])、背面平均角膜曲率 (n = 50 [18.1%]) 和正面平均角膜曲率 (n = 31 [11.2%]) 标准。使用单一基线访问标准（11 个月），中位进展时间最短，其次是 2 次基线访问（11.6 个月）、最小角膜厚度（12.1 个月）、最大角膜曲率测量（12.3 个月）、角膜散光（14.8 个月） 、中央角膜厚度（16.6 个月）、背部平均角膜曲率（18.4 个月）和前部平均角膜曲率（24.4 个月）标准。

结论

BAPD 以比传统参数更高的速度和更早的速度检测到进展。