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Fabrication of a pH-responsive core–shell nanosystem with a low-temperature photothermal therapy effect for treating bacterial biofilm infection
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-09-29 , DOI: 10.1039/d1bm01329g
Dan Peng 1 , Genhua Liu 1 , Ye He 1 , Pengfei Gao 1 , Shuangquan Gou 1 , Jing Wu 1 , Jinxiu Yu 1 , Peng Liu 1, 2 , Kaiyong Cai 1, 2
Affiliation  

Recently, photothermal therapy (PTT) has been recognized as a viable alternative strategy against bacterial biofilm infection. However, the hyperthermia required for PTT to ablate a biofilm usually induces damage in normal tissues/organs nearby. Herein, we developed zeolite-based imidazole framework (ZIF-8)-coated mesoporous polydopamine (MPDA) core–shell nanoparticles and then loaded Pifithrin-μ (PES), a natural inhibitor of heat-shock protein (HSP) that plays an essential role in bacteria resisting heating-induced damage. The ZIF-8 shell of the MPDA@ZIF-8/PES nanoplatform enabled a rapid degradation in response to the acidic environment in bacterial biofilm infection, which triggered the controlled release of PES and Zn ions. As a result, HSP was remarkably suppressed for enhancing PTT efficacy upon mild near-infrared light irradiation. In addition, the release of Zn2+ also had an antibacterial/antibiofilm effect. Thus, the fabricated nanosystem was able to induce the effective elimination of the bacterial biofilm, realizing low-temperature PTT (∼45 °C) with excellent antibacterial efficacy. This work presented here not only provides a facile approach to fabricate the MPDA@ZIF-8/PES nanosystem with the responsiveness of the bacterial infection environment, but also proposes a promising low-temperature PTT strategy to treat bacterial biofilm-infection effectively.

中文翻译:

具有低温光热治疗作用的pH响应核壳纳米系统的制备用于治疗细菌生物膜感染

最近,光热疗法 (PTT) 已被公认为对抗细菌生物膜感染的可行替代策略。然而,PTT 消融生物膜所需的热疗通常会在附近的正常组织/器官中引起损伤。在此,我们开发了基于沸石的咪唑骨架 (ZIF-8) 包覆的介孔聚多巴胺 (MPDA) 核壳纳米粒子,然后负载 Pifithrin-μ (PES),这是一种热休克蛋白 (HSP) 的天然抑制剂,起着重要的作用。在细菌抵抗加热引起的损伤中的作用。MPDA@ZIF-8/PES 纳米平台的 ZIF-8 壳能够响应细菌生物膜感染的酸性环境快速降解,从而触发 PES 和 Zn 离子的受控释放。结果,在温和的近红外光照射下,HSP被显着抑制以增强PTT功效。2+还具有抗菌/抗生物膜作用。因此,制备的纳米系统能够诱导细菌生物膜的有效消除,实现具有优异抗菌功效的低温PTT(~45°C)。本文介绍的这项工作不仅为制造具有细菌感染环境响应性的 MPDA@ZIF-8/PES 纳米系统提供了一种简便的方法,而且还提出了一种有前景的低温 PTT 策略来有效治疗细菌生物膜感染。
更新日期:2021-10-12
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