Resveratrol, as a natural antioxidant, has been studied widely for its antioxidant, anti-inflammatory, anti-apoptotic, and anticancer properties. In this study, a strategy was developed to transform and extract resveratrol from Polygonum cuspidatum on the basis of NADES (natural deep eutectic solvent). In the series of adjustments and optimizations by single-factor experimental, the optimum NADES system (choline chloride to oxalic acid was 1:1) and other experimental conditions were determined, including water content of NADES, solid-liquid ratio, extraction time, extraction temperature and ultrasonic power. At the same time, RSM combined with BBD further optimized the experimental process, the results obtained by RSM optimization showed that the resveratrol yield of 12.31 mg/g was achieved when solid-liquid ratio was 1:50, temperature was 75℃ and time was 80 min. Meantime, the conversion efficiency of polydatin was 96.11 % and the content of resveratrol increased 6-fold higher than that of untreated sample. The kinetic of extraction and thermodynamic analysis were performed at different extraction temperatures to examine the temperature on the impact of the resveratrol extraction from P. cuspidatum. Ethyl acetate was used for back extraction in order to achieve the recycling of solvent and the recovery of resveratrol from NADES. The results showed that ethyl acetate had a good extraction effect and NADES still had a high capacity to convert and extract resveratrol after three cycles. In addition, the extracts exhibited superior antioxidant activity with higher content of recovered resveratrol. This established process can therefore be used to extract and recover resveratrol from plants as an environmental, pollution-free alternative approach.

白藜芦醇作为一种天然抗氧化剂，因其抗氧化、抗炎、抗凋亡和抗癌特性而被广泛研究。本研究开发了一种从虎杖中转化和提取白藜芦醇的策略基于NADES（天然低共熔溶剂）。在通过单因素实验进行的一系列调整和优化中，确定了最佳NADES体系（氯化胆碱与草酸为1:1）和其他实验条件，包括NADES的含水量、固液比、提取时间、提取温度和超声波功率。同时RSM结合BBD进一步优化了实验工艺，RSM优化得到的结果表明，固液比为1:50、温度为75℃、时间为12.31mg/g的白藜芦醇收率达到12.31mg/g。 80 分钟 同时，虎杖苷的转化率为96.11%，白藜芦醇的含量比未处理的样品高6倍。虎杖。用乙酸乙酯进行反萃取，以实现溶剂的循环利用和从NADES中回收白藜芦醇。结果表明，乙酸乙酯具有良好的提取效果，NADES在三个循环后仍具有较高的白藜芦醇转化提取能力。此外，提取物表现出优异的抗氧化活性，回收的白藜芦醇含量更高。因此，这种既定工艺可用于从植物中提取和回收白藜芦醇，作为一种环保、无污染的替代方法。