Depression onset peaks during adolescence and young adulthood. Current treatments are only moderately effective, driving the search for novel pathophysiological mechanisms underlying youth depression. Inflammatory dysregulation has been shown in adults with depression, however, less is known about inflammation in youth depression. This systematic review identified 109 studies examining the association between inflammation and youth depression and showed subtle evidence for inflammatory dysregulation in youth depression. Longitudinal studies support the bidirectional association between inflammation and depression in youth. We hypothesise multiple inflammatory pathways contributing to depression. More research is needed on anti-inflammatory treatments, potentially tailored to individual symptom profiles.

抑郁症在青春期和成年初期达到顶峰。目前的治疗方法效果一般，这推动了对青年抑郁症背后新的病理生理机制的探索。炎症性失调已在患有抑郁症的成年人身上表现出来，然而，人们对青少年抑郁症中的炎症知之甚少。这篇系统评价确定了 109 项研究，检查炎症与青年抑郁症之间的关联，并显示了青年抑郁症中炎症失调的微妙证据。纵向研究支持青少年炎症和抑郁之间的双向关联。我们假设多种炎症途径导致抑郁症。需要对抗炎治疗进行更多研究，可能针对个体症状特征进行调整。