Studies suggest that abnormalities of the dopaminergic system underlie decision-making deficits, a hallmark of antisocial personality disorder (ASPD) and psychopathy. The dopamine transporter gene (DAT1) is of particular interest due to a polymorphism that controls dopamine transporter (DAT) activity. However, the association between DAT1 genotypes and decision-making in ASPD has never been studied. The current study investigated the effect of DAT1 genotype on decision-making, as measured by the Iowa Gambling Task (IGT), in ASPD and healthy controls. A total of 17 participants with ASPD and 16 healthy control participants without ASPD were sampled. The Hare Psychopathy Checklist-Revised and the IGT were administered to all participants. All participants provided blood samples for genotyping. Data revealed a novel interaction effect between DAT1 genotype and diagnosis, whereby ASPD participants with low DAT activity genotypes performed significantly worse on the IGT and selected from disadvantageous decks more often, whereas the low DAT activity genotype in the healthy control group was associated with better performance on the IGT, and they selected from disadvantageous decks less often. We demonstrate, for the first time, that low DAT activity genotypes in ASPD with high psychopathic traits contribute to poor decision-making.

中文翻译：

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DAT1 多态性与具有反社会人格障碍和高度精神病特征的男性决策失误有关

研究表明，多巴胺能系统异常是决策缺陷的基础，这是反社会人格障碍 (ASPD) 和精神病的标志。由于控制多巴胺转运蛋白 (DAT) 活性的多态性，多巴胺转运蛋白基因 (DAT1) 受到特别关注。然而，从未研究过 DAT1 基因型与 ASPD 决策之间的关联。目前的研究调查了 DAT1 基因型对决策制定的影响，由爱荷华赌博任务 (IGT) 衡量，在 ASPD 和健康对照中。总共抽取了 17 名患有 ASPD 的参与者和 16 名没有 ASPD 的健康对照参与者。对所有参与者进行了 Hare Psychopathy Checklist-Revised 和 IGT。所有参与者都提供了用于基因分型的血液样本。数据揭示了 DAT1 基因型与诊断之间的一种新的交互作用，即具有低 DAT 活性基因型的 ASPD 参与者在 IGT 上的表现明显更差，并且更经常地从不利的牌组中选出，而健康对照组中低 DAT 活性基因型与更好的表现相关在 IGT 上，他们从不利的套牌中选择的次数较少。我们首次证明，具有高精神病性特征的 ASPD 中的低 DAT 活性基因型会导致决策失误。他们从不利的牌组中选择的次数较少。我们首次证明，具有高精神病性特征的 ASPD 中的低 DAT 活性基因型会导致决策失误。他们从不利的牌组中选择的次数较少。我们首次证明，具有高精神病性特征的 ASPD 中的低 DAT 活性基因型会导致决策失误。