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Facile and Rapid Synthesis of Neopentyl Glycol in a Continuous-Flow Microreactor
Chemical Engineering & Technology ( IF 1.8 ) Pub Date : 2021-10-12 , DOI: 10.1002/ceat.202100164 Anming Yang 1 , Xia Yang 1 , Jincai Yue 1 , Shiqing Zheng 1 , Litao Qin 1
Chemical Engineering & Technology ( IF 1.8 ) Pub Date : 2021-10-12 , DOI: 10.1002/ceat.202100164 Anming Yang 1 , Xia Yang 1 , Jincai Yue 1 , Shiqing Zheng 1 , Litao Qin 1
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Neopentyl glycol (NPG) synthesis by condensation disproportionation of formaldehyde and isobutyraldehyde (IBD) with sodium hydroxide as catalyst was studied in a continuous-flow microreactor under various experimental conditions, such as reaction temperature, residence time, and the molar ratio of reactants. All the conditions were determined by Box-Behnken experimental design and the response surface method based on the preferred range selected by single-factor experiments. For comparison, NPG was synthesized by condensation disproportionation of the same reactants in a batch reactor. The results showed that higher NPG yield and shorter residence time were achieved in a continuous-flow microreactor than in a batch reactor when the other experimental conditions were similar.
中文翻译：
在连续流动微反应器中简便快速地合成新戊二醇
在连续流动的微反应器中，在反应温度、停留时间和反应物摩尔比等各种实验条件下，以氢氧化钠为催化剂，通过甲醛和异丁醛 (IBD) 的缩合歧化合成新戊二醇 (NPG)。所有条件均由Box-Behnken实验设计和基于单因素实验选择的优选范围的响应面法确定。为了比较，NPG 是通过在间歇反应器中相同反应物的缩合歧化来合成的。结果表明，当其他实验条件相似时，连续流动微反应器比间歇反应器获得更高的 NPG 产率和更短的停留时间。
更新日期：2021-12-16
中文翻译：
在连续流动微反应器中简便快速地合成新戊二醇
在连续流动的微反应器中，在反应温度、停留时间和反应物摩尔比等各种实验条件下，以氢氧化钠为催化剂，通过甲醛和异丁醛 (IBD) 的缩合歧化合成新戊二醇 (NPG)。所有条件均由Box-Behnken实验设计和基于单因素实验选择的优选范围的响应面法确定。为了比较，NPG 是通过在间歇反应器中相同反应物的缩合歧化来合成的。结果表明，当其他实验条件相似时，连续流动微反应器比间歇反应器获得更高的 NPG 产率和更短的停留时间。
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