Dietary polyphenol and microbiota interactions in the context of prostate health,Annals of the New York Academy of Sciences

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Dietary polyphenol and microbiota interactions in the context of prostate health
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2021-10-11 , DOI: 10.1111/nyas.14701
Jakub P Piwowarski ₁ , Iwona Stanisławska ₂ , Sebastian Granica ₁

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Recent data strongly indicate a relationship between prostate health and gut microbiota, in which composition and physiological function strictly depend on dietary patterns. The bidirectional interplay of foods containing polyphenols, such as ellagitannins, condensed tannins, lignans, isoflavones, and prenylated flavonoids with human gut microbiota, has been proven to contribute to their impact on prostate health. Considering the attributed role of dietary polyphenols in the prevention of prostate diseases, this paper aims to critically review the studies concerning the influence of polyphenols’ postbiotic metabolites on processes associated with the pathophysiology of prostate diseases. Clinical, in vivo, and in vitro studies on polyphenols have been juxtaposed with the current knowledge regarding their pharmacokinetics, microbial metabolism, and potential interactions with microbiota harboring different niches of the human organism. Directions of future research on dietary polyphenols regarding their interaction with microbiota and prostate health have been indicated.

中文翻译：

前列腺健康背景下的膳食多酚和微生物群相互作用

最近的数据强烈表明前列腺健康与肠道微生物群之间存在关系，其中组成和生理功能严格取决于饮食模式。已经证明，含有多酚的食物（例如鞣花单宁、缩合单宁、木脂素、异黄酮和异戊二烯化黄酮类化合物）与人类肠道微生物群的双向相互作用有助于它们对前列腺健康的影响。考虑到膳食多酚在预防前列腺疾病中的作用，本文旨在批判性地回顾多酚的后生元代谢物对与前列腺疾病的病理生理学相关的过程的影响的研究。临床、体内和体外对多酚的研究与目前关于其药代动力学、微生物代谢以及与具有人体不同生态位的微生物群的潜在相互作用的知识并列。已经指出了关于膳食多酚与微生物群和前列腺健康相互作用的未来研究方向。

更新日期：2021-10-11

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