Aims: The study aimed to assess the antihyperglycemic effect of Cleome arabica.

Background: Cleome arabica L. or spider flower belongs to the Capparidaceae family and it is used for treating inflammation and diabetes mellitus in traditional medicine.

Objective: This study aimed to evaluate the antihyperglycemic activity and acute toxicity of the aqueous extract of Cleome arabica L (CAAE).

Methods: The acute toxicity of CAAE was evaluated at doses of 500, 1000, or 2000 mg/kg. Parallelly, body weight, signs of toxicity, and/or mortality were observed for 14 days. The effect of oral administration of Cleome arabica aqueous extract (CAAE) at a dose of 100 mg/kg on glycemia was performed in normal and diabetic rats. Additionally, histopathological structure of the liver, phytochemical screening and in vitro antioxidant activity were studied.

Results: The acute toxicity test revealed that all treated rats survived, and no change in body weight was observed. The results demonstrated that CAAE exhibited a significant antihyperglycemic effect in diabetic rats. Furthermore, the plant extract ameliorated the liver histology in diabetic rats with a concomitant antioxidant activity.

Conclusion: This study shows that Cleome arabica is partly safe, and its LD50 seems to be greater than 5000 mg/kg. Cleome Arabica has a favorable effect against diabetes, which could be due to the presence of numerous secondary metabolites and by the protection of hepatocytes.

目的：该研究旨在评估 Cleome arabica 的抗高血糖作用。

背景：Cleome arabica L. 或蜘蛛花属于 Capparidaceae 科，在传统医学中用于治疗炎症和糖尿病。

目的：本研究旨在评估小粒樱桃水提物（CAAE）的降血糖活性和急性毒性。

方法：以 500、1000 或 2000 mg/kg 的剂量评估 CAAE 的急性毒性。同时，观察体重、毒性迹象和/或死亡率 14 天。在正常和糖尿病大鼠中以 100 mg/kg 的剂量口服 Cleome arabica 水提取物 (CAAE) 对血糖的影响。此外，还研究了肝脏的组织病理学结构、植物化学筛选和体外抗氧化活性。

结果：急性毒性试验显示所有治疗大鼠均存活，体重未见变化。结果表明，CAAE对糖尿病大鼠具有显着的降血糖作用。此外，植物提取物改善了糖尿病大鼠的肝脏组织学，同时具有抗氧化活性。

结论：这项研究表明 Cleome arabica 是部分安全的，其 LD50 似乎大于 5000 mg/kg。Cleome Arabica 具有良好的抗糖尿病作用，这可能是由于存在大量次生代谢物和保护肝细胞。