Abstract

Strychnos is an effective anti-tumor monomer with anti-inflammatory, analgesic, anti-tumor and enhancing immunity. However, its clinical application is restricted due to its poor water solubility and toxicity. The key to the study of traditional Chinese medicine strychnine is to develop a new low toxicity and high efficiency formulation. Nano liposomes can effectively improve the transdermal absorption rate of the drug, prolong the action time of the drug, enhance the tissue targeting of the drug, so as to achieve the sustained-release effect. Therefore, this paper attempts to explore the anti-inflammatory effect of traditional Chinese medicine ingredients based on the skin topical nano Strychnos liposomes, and provide experimental and theoretical basis for the development of new transdermal formulations of nano Strychnos liposomes. In this paper, Strychnos was used as the research object, and the experimental results showed that Strychnos liposomes with good dispersion stability could be prepared by film ultrasonic method. Although the composite phospholipid liposome only contains 10% hydrogenated phospholipid liposome, its peroxide value is always far lower than that of soybean phospholipid liposome, so the antioxidant capacity of composite phospholipid liposome is higher than that of soybean phospholipid liposome. Nano liposomes have almost no anti-inflammatory effect, while ordinary Strychnos has poor analgesic and anti-inflammatory effects; nano Strychnos liposomes have considerable anti-inflammatory effect.

摘要

马钱子是一种有效的抗肿瘤单体，具有抗炎、镇痛、抗肿瘤和增强免疫力的作用。但由于其水溶性差、毒性大，限制了其临床应用。中药士的宁研究的关键是开发一种新的低毒高效剂型。纳米脂质体能有效提高药物的透皮吸收率，延长药物的作用时间，增强药物的组织靶向性，从而达到缓释作用。因此，本文试图探索基于皮肤外用纳米马钱子脂质体的中药成分的抗炎作用，为开发新的纳米马钱子脂质体透皮制剂提供实验和理论依据。在本文中，以马钱子为研究对象，实验结果表明，薄膜超声法可以制备分散稳定性好的马钱子脂质体。虽然复合磷脂脂质体仅含有10%的氢化磷脂脂质体，但其过氧化值始终远低于大豆磷脂脂质体，因此复合磷脂脂质体的抗氧化能力高于大豆磷脂脂质体。纳米脂质体几乎没有抗炎作用，而普通马钱子的镇痛抗炎作用较差；纳米马钱子脂质体具有相当的抗炎作用。虽然复合磷脂脂质体仅含有10%的氢化磷脂脂质体，但其过氧化值始终远低于大豆磷脂脂质体，因此复合磷脂脂质体的抗氧化能力高于大豆磷脂脂质体。纳米脂质体几乎没有抗炎作用，而普通马钱子的镇痛抗炎作用较差；纳米马钱子脂质体具有相当的抗炎作用。虽然复合磷脂脂质体仅含有10%的氢化磷脂脂质体，但其过氧化值始终远低于大豆磷脂脂质体，因此复合磷脂脂质体的抗氧化能力高于大豆磷脂脂质体。纳米脂质体几乎没有抗炎作用，而普通马钱子的镇痛抗炎作用较差；纳米马钱子脂质体具有相当的抗炎作用。而普通马钱子的镇痛和抗炎作用较差；纳米马钱子脂质体具有相当的抗炎作用。而普通马钱子的镇痛和抗炎作用较差；纳米马钱子脂质体具有相当的抗炎作用。