Acute hepatitis A is a self-limited liver inflammation caused by hepatitis A virus (HAV) infection. The infection is transmitted by direct contact from person to person via fecal–oral routes, or through consuming contaminated food and water. This study aims to estimate the frequency of HAV infection from medical records of Tobruk Medical Center, eastern Libya and its distribution during 6 years. The medical records department of Tobruk Medical Center follows guidelines of the international classification of diseases-10 for coding the diseases. The research estimates the frequency and distribution of HAV infection based on age and sex during the period from January 2015 to December 2020. HAV screening assay was performed using commercially available enzyme-linked immunosorbent assays HAV IgM microwell. 245 cases were recorded, 53.5% of cases were males. HAV infection was the most prevalent (92.6%) in age groups of < 5–20 years. A significant rise in the occurrence of HAV infection in the last three years was reported (p < 0.05). More than half of the cases (68%) were reported in 2019 and 2020. No case fatality rate was reported in the present study. There is an increase in the frequency of HAV infection in the last 3 years and the younger age groups (under 20 years old) are more vulnerable to HAV infection. More prevention and control efforts towards this age group should be a top public health priority to avoid the possibility of HAV outbreaks in the future.

急性甲型肝炎是由甲型肝炎病毒（HAV）感染引起的一种自限性肝脏炎症。感染通过粪口途径在人与人之间直接接触，或通过食用受污染的食物和水传播。本研究旨在根据利比亚东部托布鲁克医疗中心的医疗记录及其在 6 年内的分布情况估计 HAV 感染的频率。Tobruk 医疗中心的病历部门遵循国际疾病分类指南 - 10 对疾病进行编码。该研究根据年龄和性别估计了 2015 年 1 月至 2020 年 12 月期间 HAV 感染的频率和分布。使用市售的酶联免疫吸附试验 HAV IgM 微孔进行 HAV 筛查试验。记录245例，53例。5%的病例是男性。HAV 感染在 < 5-20 岁的年龄组中最为普遍（92.6%）。据报道，过去三年 HAV 感染的发生率显着上升（p  < 0.05)。2019 年和 2020 年报告了一半以上的病例（68%）。本研究未报告病死率。在过去 3 年中，HAV 感染的频率有所增加，而年轻的年龄组（20 岁以下）更容易感染 HAV。对这一年龄组进行更多的预防和控制工作应该是公共卫生的首要任务，以避免未来爆发甲型肝炎病毒的可能性。