Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
A paper-based sensor for rapid and ultrasensitive detection of ibuprofen in water and herbal tea
Analyst ( IF 3.6 ) Pub Date : 2021-09-15 , DOI: 10.1039/d1an01533h Shaozhen Li 1 , Wenliang Ge 2 , Steven Suryoprabowo 1 , Jie Liu 1 , Hua Kuang 1 , Jianping Zhu 1 , Liqiang Liu 1 , Chuanlai Xu 1
Analyst ( IF 3.6 ) Pub Date : 2021-09-15 , DOI: 10.1039/d1an01533h Shaozhen Li 1 , Wenliang Ge 2 , Steven Suryoprabowo 1 , Jie Liu 1 , Hua Kuang 1 , Jianping Zhu 1 , Liqiang Liu 1 , Chuanlai Xu 1
Affiliation
|
As the use of non-steroidal anti-inflammatory drugs (NSAIDS) increases, their side effects have also attracted attention. Ibuprofen is one of the most widely-used NSAIDs. In this study, we screened the highly-sensitive and specific antibody 6E10, with an IC50 of 1.92 ng mL−1, and a linear range of 0.53–6.97 ng mL−1. In this study, we developed a rapid lateral flow immunochromatographic assay (ICA) strip method to detect ibuprofen in water or herbal tea. The cut-off limit of the strip is 10 ng mL−1 in water, and concentrations as low as 1 ng mL−1 can be detected in herbal tea samples, with the results obtained by the naked eye within 6 min. All the data were confirmed by high performance liquid chromatography-quadrupole time of flight-mass spectrometry (HPLC-QTOF-MS). This lateral-flow ICA strip is thus a rapid tool for on-site detection and screening of ibuprofen in water and herbal tea.
中文翻译：
一种用于快速和超灵敏检测水和凉茶中布洛芬的纸基传感器
随着非甾体抗炎药（NSAIDS）使用的增加，其副作用也引起了人们的关注。布洛芬是最广泛使用的非甾体抗炎药之一。在本研究中，我们筛选了高度敏感和特异的抗体6E10，其IC 50为1.92 ng mL -1，线性范围为0.53-6.97 ng mL -1。在这项研究中，我们开发了一种快速侧流免疫色谱法 (ICA) 条带方法来检测水或凉茶中的布洛芬。试纸在水中的临界值为 10 ng mL -1，浓度低至 1 ng mL -1可在凉茶样品中检测，肉眼可在6分钟内得到结果。所有数据均通过高效液相色谱-四极杆飞行时间-质谱（HPLC-QTOF-MS）确认。因此，这种侧流 ICA 条带是现场检测和筛选水和凉茶中布洛芬的快速工具。
更新日期：2021-10-12
中文翻译：
一种用于快速和超灵敏检测水和凉茶中布洛芬的纸基传感器
随着非甾体抗炎药（NSAIDS）使用的增加，其副作用也引起了人们的关注。布洛芬是最广泛使用的非甾体抗炎药之一。在本研究中，我们筛选了高度敏感和特异的抗体6E10，其IC 50为1.92 ng mL -1，线性范围为0.53-6.97 ng mL -1。在这项研究中，我们开发了一种快速侧流免疫色谱法 (ICA) 条带方法来检测水或凉茶中的布洛芬。试纸在水中的临界值为 10 ng mL -1，浓度低至 1 ng mL -1可在凉茶样品中检测，肉眼可在6分钟内得到结果。所有数据均通过高效液相色谱-四极杆飞行时间-质谱（HPLC-QTOF-MS）确认。因此，这种侧流 ICA 条带是现场检测和筛选水和凉茶中布洛芬的快速工具。
京公网安备 11010802027423号