Précis: 

We reduced the tube length through a small limbal incision in eyes that underwent Ahmed glaucoma valve (AGV) implantation and found that the rate of corneal endothelial cell (CEC) density was markedly reduced from −12.2% per year to −3.5% per year after this simple procedure.

Purpose: 

The aim was to evaluate the effect of postoperative tube tip trimming (TT) after AGV implantation on CEC loss.

Methods: 

In this retrospective cohort study, a total of 75 eyes from 67 patients (41 eyes in the AGV implantation only group (AGVG: mean follow-up, 42.2±13.8 mo) and 34 eyes in the TT after AGV implantation group (TAGVG: mean follow-up, 64.9±18.5 mo) were analyzed. TT was performed through a small limbal incision at a mean of 41 months after AGV implantation. Both groups were followed up for at least 1 year and underwent at least 2 specular microscopic examinations after AGV implantation and/or TT.

Results: 

In the AGVG, CEC density was reduced from 2247.0±527.3 to 1665.7±643.3 cells/mm² (P<0.001). In the TAGVG, it was reduced from 2383.1±619.4 to 1552.9±700.9 cells/mm² before TT (mean 41 mo of follow-up) and after TT, to 1394.6±654.7 cells/mm² (mean 26 mo of the follow-up). The reduction rate of CEC density before TT was −12.2±6.5% per year, and this rate was significantly reduced to −3.5±6.9% per year after TT in the TAGVG (P=0.002). The probability of corneal failure defined as a 15% reduction in CEC density was significantly reduced after TT in TAGVG (P=0.038).

Conclusions: 

Tube TT after AGV implantation markedly reduced the rate of CEC loss without serious complications in eyes with AGV implantation.

中文翻译：

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艾哈迈德青光眼瓣管部分术后修整对角膜内皮细胞损失的影响

概要： 

我们通过在接受艾哈迈德青光眼阀（AGV）植入的眼睛中通过角膜缘小切口缩短管长度，发现角膜内皮细胞（CEC）密度的比率从每年-12.2％显着降低至每年-3.5％这个简单的程序。

目的： 

目的是评估 AGV 植入术后管尖修剪(TT) 对 CEC 损失的影响。

方法： 

在这项回顾性队列研究中，共有 67 名患者的 75 只眼（仅 AGV 植入组 41 只眼（AGVG：平均随访时间，42.2±13.8 个月）和 AGV 植入后 TT 组 34 只眼（TAGVG：平均随访时间为 42.2±13.8 个月）随访时间（64.9±18.5 mo）进行分析。TT 在 AGV 植入后平均 41 个月通过角膜缘小切口进行。两组均随访至少 1 年，并在 AGV 后进行至少 2 次镜面镜检查植入和/或 TT。

结果： 

在AGVG中，CEC密度从2247.0±527.3降低至1665.7±643.3个细胞/mm ² ( P <0.001)。在TAGVG中， TT前（平均随访41个月）从2383.1±619.4减少至1552.9±700.9个细胞/mm ^{2 ，TT后减少至1394.6±654.7个细胞/mm 2}（平均随访26个月）。向上）。TAGVG中TT前CEC密度每年下降率为-12.2±6.5%，TT后该下降率显着降至每年-3.5±6.9%（P =0.002）。TAGVG 中 TT 后，定义为 CEC 密度降低 15% 的角膜失败概率显着降低（P = 0.038）。

结论： 

AGV植入后的管TT显着降低了AGV植入眼的CEC丢失率，且没有出现严重并发症。