With the continuous development of drug screening technology, new screening methodologies and technologies are constantly emerging, driving drug screening into rapid, efficient and high-throughput development. Microfluidics is a rising star in the development of innovative approaches in drug discovery. In this article, we summarize the recent years' progress of microfluidic chip technology in drug screening, including the developmental history, structural design, and applications in different aspects of microfluidic chips on drug screening. Herein, the existing microfluidic chip screening platforms are summarized from four aspects: chip structure design, sample injection and drive system, cell culture technology on a chip, and efficient remote detection technology. Furthermore, this review discusses the application and developmental prospects of using microfluidic chips in drug screening, particularly in screening natural product anticancer drugs based on chemical properties, pharmacological effects, and drug cytotoxicity.

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微流控芯片在抗癌药物筛选中的应用

随着药物筛选技术的不断发展，新的筛选方法和技术不断涌现，推动药物筛选向快速、高效、高通量的方向发展。微流体是药物发现创新方法发展的一颗冉冉升起的新星。在本文中，我们总结了近年来微流控芯片技术在药物筛选中的进展，包括微流控芯片在药物筛选中的发展历史、结构设计以及在不同方面的应用。在此，从芯片结构设计、进样驱动系统、片上细胞培养技术、高效远程检测技术四个方面对现有微流控芯片筛选平台进行总结。此外，