Improvement of Non-Alcoholic Fatty Liver Disease in Mice by Intermittent Use of a Fasting-Mimicking Diet,Molecular Nutrition & Food Research

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Improvement of Non-Alcoholic Fatty Liver Disease in Mice by Intermittent Use of a Fasting-Mimicking Diet
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2021-10-11 , DOI: 10.1002/mnfr.202100381
Jingyu Zhao ₁ , Meijuan Bai ₁ , Siying Wei ₁ , Chenchen Li ₂ , Qi Lv ₃ , Yan Chen _{1,

2}

Affiliation

Liver plays a central role in maintaining lipid homeostasis which is dysregulated in non-alcoholic fatty liver disease (NAFLD) caused by overload of dietary fat, increase in lipid synthesis, and alteration of fatty acid oxidation in the liver. In this study, we aimed to investigate whether intermittent calorie restriction using a fasting-mimicking diet (FMD) is able to slow down the progression of NAFLD in mice.

中文翻译：

间歇性使用模拟禁食饮食改善小鼠非酒精性脂肪肝

肝脏在维持脂质体内平衡方面发挥着核心作用，在非酒精性脂肪性肝病 (NAFLD) 中，由于膳食脂肪超载、脂质合成增加和肝脏中脂肪酸氧化的改变而导致脂质体内平衡失调。在这项研究中，我们旨在调查使用模拟禁食饮食 (FMD) 的间歇性卡路里限制是否能够减缓小鼠 NAFLD 的进展。

更新日期：2021-12-03

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