Many characteristics associated with Ebola virus disease remain to be fully understood. It is known that direct contact with infected bodily fluids is an associated risk factor, but few studies have investigated parameters associated with transmission between individuals, such as the dose of virus required to facilitate spread and route of infection. Therefore, we sought to characterize the impact by route of infection, viremia, and viral shedding through various mucosae, with regards to intraspecies transmission of Ebola virus in a nonhuman primate model. Here, challenge via the esophagus or aerosol to the face did not result in clinical disease, although seroconversion of both challenged and contact animals was observed in the latter. Subsequent intramuscular or intratracheal challenges suggest that viral loads determine transmission likelihood to naive animals in an intramuscular-challenge model, which is greatly facilitated in an intratracheal-challenge model where transmission from challenged to direct contact animal was observed consistently.

中文翻译：

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关键传染性参数在猕猴埃博拉病毒 Makona 传播中的作用

与埃博拉病毒病相关的许多特征仍有待充分了解。众所周知，直接接触受感染的体液是一个相关的风险因素，但很少有研究调查与个体之间传播相关的参数，例如促进传播所需的病毒剂量和感染途径。因此，我们试图通过感染途径、病毒血症和通过各种粘膜的病毒脱落来描述关于埃博拉病毒在非人类灵长类动物模型中的种内传播的影响。在这里，通过食道或气溶胶对面部的攻击不会导致临床疾病，尽管在后者中观察到攻击和接触动物的血清转化。