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DDX17-regulated alternative splicing that produced an oncogenic isoform of PXN-AS1 to promote HCC metastasis
Hepatology ( IF 12.9 ) Pub Date : 2021-10-09 , DOI: 10.1002/hep.32195
Hong-Zhong Zhou 1, 2 , Fan Li 3 , Sheng-Tao Cheng 1 , Yong Xu 2 , Hai-Jun Deng 1 , Da-Yong Gu 2 , Jin Wang 2 , Wei-Xian Chen 4 , Yu-Jiao Zhou 1 , Min-Li Yang 1 , Ji-Hua Ren 1 , Lu Zheng 5 , Ai-Long Huang 1 , Juan Chen 1
Affiliation  

The mechanism underlying HCC metastasis remains unclear, many oncogenes are known to regulate this process. However, the role of alternative splicing (AS) in pro-metastatic HCC is poorly understood.

中文翻译:

DDX17 调节的可变剪接产生 PXN-AS1 的致癌亚型以促进 HCC 转移

HCC 转移的潜在机制仍不清楚,已知许多致癌基因调节这一过程。然而,选择性剪接 (AS) 在促转移性 HCC 中的作用知之甚少。
更新日期:2021-10-09
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