Macrophage nuclear factor erythroid 2-related factor 2 deficiency promotes innate immune activation by tissue inhibitor of metalloproteinase 3–mediated RhoA/ROCK pathway in the ischemic liver,Hepatology

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Macrophage nuclear factor erythroid 2-related factor 2 deficiency promotes innate immune activation by tissue inhibitor of metalloproteinase 3–mediated RhoA/ROCK pathway in the ischemic liver
Hepatology ( IF 12.9 ) Pub Date : 2021-10-08 , DOI: 10.1002/hep.32184
Jianhua Rao _{1,

2,

3} , Jiannan Qiu _{1,

2} , Ming Ni _{1,

2} , Hao Wang _{1,

2} , Peng Wang _{1,

2} , Lei Zhang _{1,

2} , Zeng Wang _{1,

2} , Mu Liu _{1,

2} , Feng Cheng _{1,

2} , Xuehao Wang _{1,

2,

3} , Ling Lu _{1,

2,

3}

Affiliation

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of reactive oxygen species (ROS) and inflammation and has been implicated in both human and murine inflammatory disease models. We aimed to characterize the roles of macrophage-specific Nrf2 in liver ischemia/reperfusion injury (IRI).

中文翻译：

巨噬细胞核因子红细胞2相关因子2缺乏通过金属蛋白酶3组织抑制剂介导的缺血性肝脏中RhoA/ROCK途径促进先天免疫激活

核因子红细胞 2 相关因子 2 (Nrf2) 是活性氧 (ROS) 和炎症的主要调节因子，与人类和小鼠炎症疾病模型有关。我们的目的是表征巨噬细胞特异性 Nrf2 在肝脏缺血/再灌注损伤 (IRI) 中的作用。

更新日期：2021-10-08

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