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Macrophage nuclear factor erythroid 2-related factor 2 deficiency promotes innate immune activation by tissue inhibitor of metalloproteinase 3–mediated RhoA/ROCK pathway in the ischemic liver
Hepatology ( IF 12.9 ) Pub Date : 2021-10-08 , DOI: 10.1002/hep.32184
Jianhua Rao 1, 2, 3 , Jiannan Qiu 1, 2 , Ming Ni 1, 2 , Hao Wang 1, 2 , Peng Wang 1, 2 , Lei Zhang 1, 2 , Zeng Wang 1, 2 , Mu Liu 1, 2 , Feng Cheng 1, 2 , Xuehao Wang 1, 2, 3 , Ling Lu 1, 2, 3
Affiliation  

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of reactive oxygen species (ROS) and inflammation and has been implicated in both human and murine inflammatory disease models. We aimed to characterize the roles of macrophage-specific Nrf2 in liver ischemia/reperfusion injury (IRI).

中文翻译:


巨噬细胞核因子红细胞2相关因子2缺乏通过金属蛋白酶3组织抑制剂介导的缺血性肝脏中RhoA/ROCK途径促进先天免疫激活



核因子红细胞 2 相关因子 2 (Nrf2) 是活性氧 (ROS) 和炎症的主要调节因子,与人类和小鼠炎症疾病模型有关。我们的目的是表征巨噬细胞特异性 Nrf2 在肝脏缺血/再灌注损伤 (IRI) 中的作用。
更新日期:2021-10-08
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