Strategies to Generate Nitrogen-centered Radicals That May Rely on Photoredox Catalysis: Development in Reaction Methodology and Applications in Organic Synthesis,Chemical Reviews

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Strategies to Generate Nitrogen-centered Radicals That May Rely on Photoredox Catalysis: Development in Reaction Methodology and Applications in Organic Synthesis
Chemical Reviews ( IF 51.4 ) Pub Date : 2021-10-08 , DOI: 10.1021/acs.chemrev.1c00444
Kitae Kwon ₁ , R Thomas Simons ₁ , Meganathan Nandakumar ₁ , Jennifer L Roizen ₁

Affiliation

For more than 70 years, nitrogen-centered radicals have been recognized as potent synthetic intermediates. This review is a survey designed for use by chemists engaged in target-oriented synthesis. This review summarizes the recent paradigm shift in access to and application of N-centered radicals enabled by visible-light photocatalysis. This shift broadens and streamlines approaches to many small molecules because visible-light photocatalysis conditions are mild. Explicit attention is paid to innovative advances in N–X bonds as radical precursors, where X = Cl, N, S, O, and H. For clarity, key mechanistic data is noted, where available. Synthetic applications and limitations are summarized to illuminate the tremendous utility of photocatalytically generated nitrogen-centered radicals.

中文翻译：

可能依赖于光氧化还原催化产生以氮为中心的自由基的策略：反应方法的发展及其在有机合成中的应用

70 多年来，以氮为中心的自由基一直被认为是有效的合成中间体。本综述是一项旨在供从事目标导向合成的化学家使用的调查。这篇综述总结了最近通过可见光光催化获得和应用N中心自由基的范式转变。由于可见光光催化条件温和，这种转变拓宽并简化了许多小分子的研究方法。明确关注 N-X 键作为自由基前体的创新进展，其中 X = Cl、N、S、O 和 H。为了清楚起见，在可用的情况下标注了关键机械数据。总结了合成应用和局限性，以阐明光催化产生的氮中心自由基的巨大效用。

更新日期：2021-10-08

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