On the cover: Over the past decade, tremendous progress in basic science arenas, including cell biology and bioengineering, coupled with wide-ranging technological advances from gene editing to normothermic perfusion platforms have exploded the horizon of opportunity for cellular therapies. Parsons et al. (page 3225) paint the current landscape. They begin with familiar applications of islet and hepatocyte transplantation and progress to cellular infusions for immunomodulation and tolerance induction. The minireview ends in the brave new world of tissue engineering and regenerative medicine, delineating the essential steps of three-dimensional bioprinting and then summarizing recent advances in the generation of tissues and organs. In the same vein, we are excited to present a landmark case of tracheal transplantation for traumatic injury resulting in long-segment cricotracheal stenosis. Genden and colleagues (page 3421), after years of innovation and refinement in canine models, elegantly succeeded where many have failed, achieving a well- vascularized, 11.5 cm graft extending from the cricoid cartilage to the carina. Cover design by Megan Llewellyn, Duke University Section of Surgical Disciplines.

中文翻译：

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美国移植杂志：第 21 卷，第 10 期，2021 年 10 月

在封面：在过去十年中，包括细胞生物学和生物工程在内的基础科学领域的巨大进步，加上从基因编辑到常温灌注平台的广泛技术进步，为细胞疗法开辟了广阔的前景。帕森斯等人。（第 3225 页）绘制当前的风景。他们从熟悉的胰岛和肝细胞移植应用开始，然后发展到用于免疫调节和耐受诱导的细胞输注。这篇小综述以组织工程和再生医学的美丽新世界结束，描绘了生物三维打印的基本步骤，然后总结了组织和器官生成的最新进展。同样，我们很高兴地介绍一个具有里程碑意义的气管移植案例，用于治疗导致长节段环气管狭窄的外伤性损伤。Genden 及其同事（第 3421 页）经过多年对犬模型的创新和改进，在许多失败的地方取得了优雅的成功，实现了血管化良好的 11.5 cm 移植物，从环状软骨延伸到隆突。封面设计由杜克大学外科学科部的 Megan Llewellyn 设计。